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Androgen Receptor (AR) (N-Term) antibody

Antigen

Androgen Receptor (AR)
Synonyms KD, AIS, TFM, DHTR, SBMA, HYSP1, NR3C4, SMAX1, HUMARA, Tfm, AW320017, Andr, AR, DKFZp468G2216
Epitope
Alternatives

N-Term
Clonality Polyclonal
Host
Reactivity
Alternatives

Cow (Bovine)
Application
Alternatives Western Blotting (WB), Enzyme Immunoassay (EIA)
Catalog no. ABIN374452
Quantity 0.1 mg  (0.5 mg/ml)  (Variants)
Price 290.00 $   Plus shipping costs $35.00
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Availability Ships within 7 to 10 Business Days

Additional Information
Application Details Alternatives Secondary Antibodies Variants back to top

Characteristics Synonyms: Dihydrotestosterone receptor, DHTR, NR3C4, Nuclear receptor subfamily 3 group C member4
Alternative name Androgen receptor
Gene ID 367
Swiss-Prot P10275
Immunogen Peptide from the N Terminus of the protein sequence according to NP_000035AA Sequence: EVQLGLGRVYPRPPSC
Cross-Reactivity Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
Description The androgen receptor (AR) is a 110 kDa androgen-dependent transcription factor that is amember of the steroid/nuclear receptor gene superfamily. The AR signaling pathway playsa key role in development and function of male reproductive organs, including the prostateand epididymis. AR also plays a role in nonreproductive organs, such as muscle, hairfollicles, and brain. Abnormalities in the AR signaling pathway have been linked to anumber of diseases, including prostate cancer, Kennedy's disease and male infertility. ThePI3K/Akt signaling pathway plays an important role in regulating AR activity throughphosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines mayinduce phosphorylation of AR through the PI3K/Akt pathway. Activation of the PI3K/AKtpathway is thought to have a survival role in prostate cancer by protecting cells fromapoptosis.
Specificity This antibody recognizes Androgen Receptor.

Application Details
Alternatives Secondary Antibodies Variants back to top

Application Notes Peptide ELISA: 1/64,000. Western Blot: 0.3-2.0 µg/ml. Detects a band of Approx 95kDa in Human Brain and HumanHeart lysates(Predicted Molecular Weight: 99kDa). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
Purification Aff - Purified
Buffer Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and0.5% BSA as stabilizer.
Storage Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Research Area Hormones, Receptors
Restrictions For Research Use only

Alternatives
Application Details Secondary Antibodies Variants back to top

Alternatives for antigen "Androgen Receptor (AR)", type "Antibodies"
Hosts Rabbit (79), Mouse (15), Goat (5), Rat (1)
Reactivities Human (90), Mouse (Murine) (39), Rat (Rattus) (35), Cow (Bovine) (18), Pig (Porcine) (18), Horse (Equine) (16), Rabbit (16), Chicken (15), Sheep (Ovine) (15), Dog (Canine) (6), Primate (2), Cat (Feline) (1), Chimpanzee (1), Goat (1), Lizard (1)
Applications Western Blotting (WB) (54), Immunofluorescence (IF) (36), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (36), Flow Cytometry (FACS) (18), ELISA (17), Immunohistochemistry (IHC) (14), Enzyme Immunoassay (EIA) (13), Immunoprecipitation (IP) (13), Immunohistochemistry (Frozen Sections) (IHC (fro)) (10), Dot Blot (Dot) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitopes pSer213 (8), pSer650 (8), N-Term (7), Ab-650 (5), Ab-1 (1), Ab-213 (1), Ab-363 (1), Ab-94 (1), pSer94 (1), pTyr363 (1)