Androgen Receptor antibody

Catalog No. ABIN1724724

Product Details anti-Androgen Receptor Antibody

Target: Androgen Receptor (AR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Androgen Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: purified

Immunogen: Purified recombinant fragment of human AR expressed in E. coli.

Clone: 2H8

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-Androgen Receptor antibody (ABIN1724724)

Yu, Han, Shao, Wu, Zhao, Liu, Sun, Tang, Xia: "Androgen receptor functioned as a suppressor in the prostate cancer cell line PC3 in vitro and in vivo." in: Chinese medical journal, Vol. 122, Issue 22, pp. 2779-83, (2009) (PubMed).

Hsu, Lan, Tsai, Ou, Cheng, Tsai, Kang, Tung, Wong, Huang: "Expression of androgen receptor in human placentas from normal and preeclamptic pregnancies." in: Taiwanese journal of obstetrics & gynecology, Vol. 48, Issue 3, pp. 262-7, (2009) (PubMed).

Tillman, Yuan, Gu, Fazli, Ghosh, Flynt, Gleave, Rennie, Kasper: "DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells." in: Cancer research, Vol. 67, Issue 10, pp. 4630-7, (2007) (PubMed).

Target Details for Androgen Receptor

Target: Androgen Receptor (AR)

Alternative Name: Androgen receptor (AR Products)

Synonyms: AIS antibody, DHTR antibody, HUMARA antibody, HYSP1 antibody, KD antibody, NR3C4 antibody, SBMA antibody, SMAX1 antibody, TFM antibody, AW320017 antibody, Tfm antibody, Andr antibody, AR antibody, androgen receptor antibody, AR antibody, Ar antibody, ar antibody

Background:

Description: The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA binding transcription factor which regulates gene expression, however, the androgen receptor has other functions as well. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype.

Aliases: NR3C4, KD, AIS, SMAX1, HUMARA, AR

Molecular Weight: 110 kDa

Gene ID: 367

HGNC: 367

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding