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Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) (Internal Region) antibody

Details for Product No. ABIN374587, Supplier: Log in to see
Antigen
  • KLRK1
  • NKG2D
  • CD314
  • D12S2489E
  • KLR
  • NKG2-D
  • D6H12S2489E
  • Nkg2d
  • Nkrp2
  • killer cell lectin-like receptor subfamily K, member 1
  • NKG2-D type II integral membrane protein-like
  • NKG2D protein
  • KLRK1
  • LOC100398970
  • Klrk1
  • NKG2D
Alternatives
anti-Human Killer Cell Lectin-Like Receptor Subfamily K, Member 1 antibody for Functional Studies
Epitope
Internal Region
16
15
7
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
153
65
19
4
3
2
Host
Goat
100
39
31
16
11
2
Clonality
Polyclonal
Conjugate
Un-conjugated
26
20
11
6
6
5
5
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
137
49
44
28
25
25
25
16
13
7
6
5
5
5
3
2
2
1
1
1
Options
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Immunogen Peptide with sequence C-KVYSKEDQDLLK, from the internal region of the protein sequence
Specificity This antibody reacts to CD314.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name CD314 / KLRK1 (KLRK1 Antibody Abstract)
Background NKG2D is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. NKG2D forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of NKG2D include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding to NKG2D results in NK cell activation and potent costimulation of effector T cells.Synonyms: D12S2489E, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, NKG2D
Gene ID 22914, 9606
UniProt P26718
Pathways Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) (Internal Region) antibody (ABIN374587) anti-Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) (Internal Region) antibody
Background publications Hayakawa, Smyth: "Innate immune recognition and suppression of tumors." in: Advances in cancer research, Vol. 95, pp. 293-322, 2006 (PubMed).