Stathmin 1 antibody (C-Term)

Catalog No. ABIN374648

Product Details anti-Stathmin 1 Antibody

Target: Stathmin 1 (STMN1)

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Goat

Clonality: Polyclonal

Conjugate: This Stathmin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody is expected to cross-react with isoform 1a (NP_005554.1, NP_981944.1, NP_981946.1) only. The three reported isoforms (NP_005554.1, NP_981944.1 and NP_981946.1) represent identical protein.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide (C-KNKESKDPADETEAD) from C-terminus of Human STMN1 (NP_005554.1, NP_981944.1, NP_981946.1)

Application Details

Application Notes: ELISA: 1/1000. Western Blot: 1-3 μg/mL. Immunohistochemistry on Paraffin Sections: 3.75 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-Stathmin 1 antibody (ABIN374648)

Watabe-Rudolph, Song, Lausser, Schnack, Begus-Nahrmann, Scheithauer, Rettinger, Otto, Tumani, Thal, Attems, Jellinger, Kestler, von Arnim, Rudolph: "Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease." in: Neurology, Vol. 78, Issue 8, pp. 569-77, (2012) (PubMed).

Wallukat, Muñoz Saravia, Haberland, Bartel, Araujo, Valda, Duchen, Diaz Ramirez, Borges, Schimke: "Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients." in: Journal of the American College of Cardiology, Vol. 55, Issue 5, pp. 463-8, (2010) (PubMed).

Target Details for Stathmin 1

Target: Stathmin 1 (STMN1)

Alternative Name: Stathmin / STMN1 (STMN1 Products)

Synonyms: C1orf215 antibody, LAP18 antibody, Lag antibody, OP18 antibody, PP17 antibody, PP19 antibody, PR22 antibody, SMN antibody, 19k antibody, Lap18 antibody, Op18 antibody, P18 antibody, P19 antibody, Pig antibody, Pp17 antibody, Pp18 antibody, Pp19 antibody, Pr22 antibody, Smn antibody, prosolin antibody, op18 antibody, stathmin antibody, stmn1 antibody, stmn1a antibody, lag antibody, lap18 antibody, pp17 antibody, pp19 antibody, pr22 antibody, smn antibody, fj43c10 antibody, wu:fj38b07 antibody, wu:fj43c10 antibody, zgc:110159 antibody, cb959 antibody, wu:fb14e04 antibody, zgc:136942 antibody, stmn1-a antibody, stmn1b antibody, xo35 antibody, stathmin 1 antibody, stathmin 1 S homeolog antibody, stathmin 1b antibody, stathmin 1a antibody, stathmin-like antibody, stathmin antibody, stathmin 1 L homeolog antibody, STMN1 antibody, Stmn1 antibody, stmn1.S antibody, stmn1 antibody, stmn1b antibody, stmn1a antibody, LOC100229194 antibody, stmn1.L antibody

Background: STMN1 is a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Alternatively spliced transcript variants encoding the same protein have been identified.Synonyms: LAP18, Leukemia-associated phosphoprotein p18, Metablastin, OP18, Oncoprotein 18, Op18, Phosphoprotein p19, Prosolin, Protein Pr22, pp17, pp19

Molecular Weight: 17.3kDa (NP_005554.1, NP_981944.1 and NP_981946.1).

Gene ID: 3925, 9606

UniProt: P16949

Pathways: MAPK Signaling, Microtubule Dynamics