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Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (Internal Region) antibody

Details for Product No. ABIN374681, Supplier: Log in to see
Antigen
  • CG17947
  • CT39986
  • Dalpha-Cat
  • Dalpha-cat
  • DalphaC
  • Dalphacat
  • Dmcatp
  • Dmel\\CG17947
  • a-Cat
  • a-cat
  • alpha-CAT
  • alpha-cat
  • alpha-catenin
  • alpha-ctn
  • alphaCAT
  • alphaCat
  • alphacat
  • Alpha-Cat
  • dgri_GLEANR_3829
  • DgriGH19548
  • GH19548
  • 2010010M04Rik
  • AA517462
  • AI988031
  • Catna1
  • ctnna
  • CAP102
  • CTNNA1
Epitope
Internal Region
24
17
12
6
4
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
129
65
39
5
4
1
1
1
Host
Goat
95
20
16
2
Clonality
Polyclonal
Conjugate
Un-conjugated
2
1
1
1
1
1
1
1
Application
Western Blotting (WB)
117
51
51
21
21
15
9
7
5
4
3
2
1
1
Supplier
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Immunogen Peptide with sequence C-KREKQDETQTKIK, from the internal region of the protein sequence
Specificity This antibody reacts to Catenin alpha-1 / CTNNA1.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name Catenin alpha-1 / CTNNA1 (CTNNA1 Antibody Abstract)
Background The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.Synonyms: Alpha Catenin, Alpha E-catenin, Cadherin-associated protein, NY-REN-13 antigen
Gene ID 1495, 9606
UniProt P35221
Research Area Signaling
Application Notes Peptide ELISA: 1/32000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (Internal Region) antibody (ABIN374681) anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (Internal Region) antibody
Background publications Lynch, Grady, Suriano et al.: "Gastric cancer: new genetic developments." in: Journal of surgical oncology, Vol. 90, Issue 3, pp. 114-33; discussion 133, 2005 (PubMed).

Troncone, Anderson, Herrington et al.: "Comparative analysis of human papillomavirus detection by dot blot hybridisation and non-isotopic in situ hybridisation." in: Journal of clinical pathology, Vol. 45, Issue 10, pp. 866-70, 1992 (PubMed).