Serotonin Receptor 3A antibody (Internal Region)

Catalog No. ABIN374713

This Goat Polyclonal antibody specifically detects Serotonin Receptor 3A in WB, IF and EIA. It exhibits reactivity toward Human and Rat. It has been mentioned in 2+ publications

Quick Overview for Serotonin Receptor 3A antibody (Internal Region) (ABIN374713)

Target: Serotonin Receptor 3A (HTR3A)

Reactivity: Human, Rat

Host: Goat

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 3A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-Serotonin Receptor 3A Antibody

Binding Specificity: Internal Region

Sequence: C-GPQDFEKSPR DR

Specificity: This antibody is expected to recognize all three reported isoforms (NP_998786.2, NP_000860.2, NP_001155244.1).

Cross-Reactivity (Details): Species reactivity (tested):Human, Rat.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence Genename: HTR3A

Application Details

Application Notes: ELISA: 1/128000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-Serotonin Receptor 3A antibody (ABIN374713)

do Amaral, Ueno, Oliveira, Borsonello, Vanzela, Ribeiro, Alves, Barbosa, Carneiro, Boschero: "Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats." in: The Journal of nutritional biochemistry, Vol. 22, Issue 6, pp. 554-9, (2011) (PubMed).

Lu, Hsieh, Dun, Oprea, Wang, Luo, Lin, Chang, Lee: "Estrogen rapidly modulates 5-hydroxytrytophan-induced visceral hypersensitivity via GPR30 in rats." in: Gastroenterology, Vol. 137, Issue 3, pp. 1040-50, (2009) (PubMed).

Target Details for Serotonin Receptor 3A

Target: Serotonin Receptor 3A (HTR3A)

Background: 5-hydroxytryptamine (serotonin) receptors is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The 5HT3A receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.Synonyms: 5-HT3A, 5-HT3R, 5-hydroxytryptamine receptor 3A, Serotonin-gated ion channel receptor

Gene ID: 3359

NCBI Accession: NP_000860

UniProt: P46098

Pathways: Synaptic Membrane