Serotonin Receptor 3A antibody (N-Term)

Catalog No. ABIN2792275

There is 1 publication for this product available. The Rabbit Polyclonal anti-Serotonin Receptor 3A antibody is suitable to detect Serotonin Receptor 3A in samples from Human, Rat, Mouse, Dog, Cow and Horse. It has been validated for WB and IHC.

Quick Overview for Serotonin Receptor 3A antibody (N-Term) (ABIN2792275)

Target: Serotonin Receptor 3A (HTR3A)

Reactivity: Human, Rat, Mouse, Dog, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 3A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Serotonin Receptor 3A Antibody

Binding Specificity: N-Term

Purpose: HTR3A Antibody - N-terminal region

Sequence: LLLPTLLAQG EARRSRNTTR PALLRLSDYL LTNYRKGVRP VRDWRKPTTV

Predicted Reactivity: Cow: 78%, Dog: 78%, Horse: 91%, Human: 100%, Mouse: 78%, Rat: 78%

Characteristics: This is a rabbit polyclonal antibody against HTR3A. It was validated on Western Blot using a cell lysate as a positive control.

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HTR3A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-Serotonin Receptor 3A antibody (ABIN2792275)

Rinaldi, Chiaravalli, Mian, Zucca, Tibiletti, Capella, Bertoni: "Serotonin receptor 3A expression in normal and neoplastic B cells." in: Pathobiology : journal of immunopathology, molecular and cellular biology, Vol. 77, Issue 3, pp. 129-35, (2010) (PubMed).

Target Details for Serotonin Receptor 3A

Target: Serotonin Receptor 3A (HTR3A)

Alternative Name: HTR3A

Background:

Background Information: HTR3A belongs to the ligand-gated ion channel receptor superfamily. It is the subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic

Alternative Symbols: HTR3, 5HT3R, 5-HT-3, 5-HT3A, 5-HT3R

Protein Name: 5-hydroxytryptamine receptor 3A

Molecular Weight: 55 kDa

Gene ID: 3359

NCBI Accession: NP_000860

UniProt: P46098

Pathways: Synaptic Membrane