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Cerebral Cavernous Malformation 2 (CCM2) (Internal Region) antibody

Details for Product No. ABIN374751
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Antigen
Synonyms malcavernin, CCM2, C7orf22, OSM, BC029157
Epitope
Internal Region
(4), (3), (2), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(41), (13), (13), (12), (1)
Host
Goat
(19), (19), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(32), (19), (10), (4), (4), (4), (2), (2)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN374751
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Immunogen Peptide with sequence C-KGEKSRDKKAHEK, from the internal region of the protein sequence
Specificity This antibody reacts to Malcavernin. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat, Canine.
Purification Affinity chromatography
Alternative Name Malcavernin
Background CCM2 may function as a scaffold protein for MAP2K3-MAP3K3 signaling. It seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
Alternate names: C7orf22, CCM2, Cerebral cavernous malformations 2 protein, PP10187
Gene ID 83605
NCBI Accession 9606
UniProt Q9BSQ5
Application Notes Peptide ELISA: 1/128000. Western Blot: 0.03 - 0.1 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody in aliquots at -20°C.
Expiry Date 12 months
Supplier Images
anti-Cerebral Cavernous Malformation 2 (CCM2) (Internal Region) antibody anti-Cerebral Cavernous Malformation 2 (CCM2) (Internal Region) antibody
Background publications Zawistowski, Stalheim, Uhlik et al.: "CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis." in: Human molecular genetics, Vol. 14, Issue 17, pp. 2521-31, 2005 (PubMed).

Validation Images
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