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CCM2 antibody (Cerebral Cavernous Malformation 2) (Internal Region)

Details for Product anti-CCM2 Antibody No. ABIN374751, Supplier: Log in to see
Antigen
  • malcavernin
  • CCM2
  • C7orf22
  • OSM
  • BC029157
Epitope
Internal Region
11
5
2
2
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
57
8
8
2
2
1
1
1
1
1
Host
Goat
32
14
11
Clonality
Polyclonal
Conjugate
This CCM2 antibody is un-conjugated
1
1
1
1
1
1
1
Application
Western Blotting (WB)
51
26
13
8
3
2
Supplier
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Immunogen Peptide with sequence C-KGEKSRDKKAHEK, from the internal region of the protein sequence
Specificity This antibody reacts to Malcavernin.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name Malcavernin (CCM2 Antibody Abstract)
Background CCM2 may function as a scaffold protein for MAP2K3-MAP3K3 signaling. It seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.Synonyms: C7orf22, CCM2, Cerebral cavernous malformations 2 protein, PP10187
Gene ID 83605, 9606
UniProt Q9BSQ5
Pathways
Application Notes Peptide ELISA: 1/128000. Western Blot: 0.03 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody in aliquots at -20 °C.
Supplier Images
 image for anti-CCM2 antibody (Cerebral Cavernous Malformation 2) (Internal Region) (ABIN374751) anti-Cerebral Cavernous Malformation 2 (CCM2) (Internal Region) antibody
Background publications Zawistowski, Stalheim, Uhlik et al.: "CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis." in: Human molecular genetics, Vol. 14, Issue 17, pp. 2521-31, 2005 (PubMed).