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CACNA2D1 antibody (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1) (Internal Region)

Details for Product anti-CACNA2D1 Antibody No. ABIN374788, Supplier: Log in to see
Antigen
  • Ca(v)alpha2delta1
  • Cacna2
  • CACNA2
  • CACNA2D1
  • CACNL2A
  • Cchl2a
  • CCHL2A
  • CCHLA2
  • DHSCCA
  • DKFZp469K2211
Epitope
Internal Region
23
12
4
2
2
2
1
1
1
Reactivity
Human
64
14
13
4
2
2
1
1
1
1
Host
Goat
54
14
Clonality
Polyclonal
Conjugate
This CACNA2D1 antibody is un-conjugated
5
5
5
3
3
3
Application
Western Blotting (WB)
55
37
11
8
4
2
1
1
Supplier
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Immunogen Synthetic peptide from the internal region of Human CACNA2D1 (NP_000713.2) Genename: CACNA2D1
Sequence C-QEIFNKYNKD KKVR
Specificity This antibody recognizes CACNA2D1.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name CACNA2D1 (CACNA2D1 Antibody Abstract)
Background Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling. The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling. The purified DHP receptor isolated from triads is composed of at least four subunits. The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel. The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied. The other two subunits that co-purify with the DHP receptor are termed beta and gamma.Synonyms: CACNL2A, CCHL2A, MHS3, Voltage-dependent calcium channel subunit alpha-2/delta-1
Molecular Weight 123 kDa (NP_000713.2)
Gene ID 781, 9606
UniProt P54289
Application Notes Peptide ELISA: 1/16000. Western Blot: 0.03 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-CACNA2D1 antibody (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1) (Internal Region) (ABIN374788) anti-Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) (Internal Region) antibody
Background publications Neely, Hess, Costigan, Keene, Goulas, Langeslag, Griffin, Belfer, Dai, Smith, Diatchenko, Gupta, Xia, Amann, Kreitz, Heindl-Erdmann, Wolz, Ly, Arora, Sarangi, Dan, Novatchkova, Rosenzweig, Gibson, Truong, Schramek, Zoranovic, Cronin, Angjeli, Brune, Dietz: "A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene." in: Cell, Vol. 143, Issue 4, pp. 628-38, 2010