CACNB4
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Peptide ELISA: 1/4000. Western Blot: 0.2 - 0.6 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
0,5 mg/mL
Buffer
Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. CACNB4 is expressed predominantly in the cerebellum and kidney. Defects in CACNB4 are a cause of idiopathic generalized epilepsy (IGE). IGE is characterized by recurrent generalized seizures. Defects in CACNB4 are also a cause of juvenile myoclonic epilepsy (JME). JME is a common epileptic syndrome characterized by afebrile seizures, onset in adolescence (rather than in childhood) and myoclonic jerks.Synonyms: CAB4, CACNLB4, Calcium channel voltage-dependent subunit beta 4, Voltage-dependent L-type calcium channel subunit beta-4