Angiotensin I Converting Enzyme 1 antibody

Catalog No. ABIN379980

The Mouse Monoclonal anti-Angiotensin I Converting Enzyme 1 antibody (Clone CG2) (ABIN379980) specifically detects Angiotensin I Converting Enzyme 1 in IHC and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Angiotensin I Converting Enzyme 1 antibody (ABIN379980)

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Angiotensin I Converting Enzyme 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CG2

Product Details anti-Angiotensin I Converting Enzyme 1 Antibody

Specificity: The antigen is CD143, the epitope is apparently localized in the N-terminal portion of the protein. Antigen distribution: Tissue sections: Topographically the degree of expression correlates with the proportion of smooth muscle cells and elastic fibres of the vessel wall. ACE is predominantely expressed by small muscular arteries and by arterioles, whereas small and large veins do not usually express ACE. However, no ACE could be detected in the endothelial cells of kidney. Constitutively ACE is expressed on endothelial cells in different diseases like hypertension, myocardial infarction, sarcoidosis, diabetes. Specificity: Human: denatured ACE. Other species: not tested.

Purification: Affinity purified

Immunogen: purified ACE from human lung and kidney

Application Details

Application Notes: Approved: IHC, IHC-P (1:50)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.5 mL distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS  pH 7.2, 10 mg/mL BSA, 0.1 % Kathon

Preservative: Kathon CG

Storage: 4 °C

Storage Comment: Store at 4°C.

Target Details for Angiotensin I Converting Enzyme 1

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Alternative Name: ACE / DCP1 / CD143

Background: Name/Gene ID: ACE
Subfamily: Metallopeptidase M2
Family: Protease

Synonyms: ACE, ACE1, Angiotensin-converting enzyme, CD143, CD143 antigen, Carboxycathepsin, DIPEPTIDYL CARBOXYPEPTIDASE, DCP, Dipeptidyl carboxypeptidase I, ICH, Kininase II, MVCD3, Peptidyl-dipeptidase A, Peptidase P, DCP1, Dipeptidyl carboxypeptidase 1, Testicular ECA

Gene ID: 1636

UniProt: P12821

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration