Angiotensin I Converting Enzyme 1 antibody (AA 30-270)

Catalog No. ABIN3016740

The Rabbit Polyclonal anti-Angiotensin I Converting Enzyme 1 antibody is suitable to detect Angiotensin I Converting Enzyme 1 in samples from Human. It has been validated for WB and IHC.

Quick Overview for Angiotensin I Converting Enzyme 1 antibody (AA 30-270) (ABIN3016740)

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Angiotensin I Converting Enzyme 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Angiotensin I Converting Enzyme 1 Antibody

Binding Specificity: AA 30-270

Sequence: EASQQVTVTH GTSSQATTSS QTTTHQATAH QTSAQSPNLV TDEAEASKFV EEYDRTSQVV WNEYAEANWN YNTNITTETS KILLQKNMQI ANHTLKYGTQ ARKFDVNQLQ NTTIKRIIKK VQDLERAALP AQELEEYNKI LLDMETTYSV ATVCHPNGSC LQLEPDLTNV MATSRKYEDL LWAWEGWRDK AGRAILQFYP KYVELINQAA RLNGYVDAGD SWRSMYETPS LEQDLERLFQ E

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-270 of human ACE11 (NP_690043.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Angiotensin I Converting Enzyme 1

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Alternative Name: ACE

Background: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.,ACE,ACE1,CD143,DCP,DCP1,angiotensin-converting enzyme,ICH,MVCD3,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,Endocrine & Metabolism,Immunology & Inflammation,CD markers,Stem Cells,Hematopoietic Progenitors,Cardiovascular,Blood,Serum Proteins,Hypoxia,ACE

Molecular Weight: 78 kDa/83 kDa/131 kDa/149 kDa

Gene ID: 1636

UniProt: P12821

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration