ATG12 antibody (Autophagy Related 12)

Details for Product anti-ATG12 Antibody No. ABIN387794, Supplier: Log in to see
Antigen
  • APG12
  • APG12L
  • FBR93
  • HAPG12
  • Apg12l
  • AUTOPHAGY 12
  • AUTOPHAGY 12 B
  • CG10861
  • Dmel\\CG10861
  • atg12
  • ATG12
  • apg12
  • DDBDRAFT_0185323
  • DDBDRAFT_0191412
  • DDB_0185323
  • DDB_0191412
  • 4931423H11Rik
  • A330058M13Rik
  • Atg12l
  • AO090001000593
  • autophagy related 12
  • ubiquitin-like protein ATG12B
  • Atg12p
  • autophagy protein
  • APG12/APG12B
  • autophagy associated protein Atg12
  • Autophagy-specific gene 12
  • ATG12 autophagy related 12 homolog (S. cerevisiae)
  • autophagy associated ubiquitin-like modifier Atg12
  • similar to S. cerevisiae ATG12 (YBR217W) which nucleates preautophagosome formation as a conjugate with Atg5
  • Autophagy-related protein 12 (Autophagy-related ubiquitin-like modifier ATG12)
  • autophagy protein 12
  • autophagy-related protein 12
  • ATG12
  • Atg12
  • APG12B
  • APG12
  • ARALYDRAFT_318184
  • apg12
  • atg12
  • ANI_1_922094
  • AOR_1_1064164
Alternatives
anti-Human ATG12 antibody for ELISA
Reactivity
Human
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Host
Mouse
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Clonality (Clone)
Monoclonal ()
Conjugate
This ATG12 antibody is un-conjugated
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Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Options
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Immunogen APG12L recombinant protein is used to produce this monoclonal antibody.
Clone 43CT73-3-5-5-4
Isotype IgG2b kappa
Specificity APG12L recombinant protein is used to produce this monoclonal antibody.
Purification This antibody is purified through a protein A column, followed by dialysis against PBS.
Alternative Name ATG12 (ATG12 Antibody Abstract)
Background Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).
Synonyms: APG12, APG12L, FBR93, HAPG12, APG12 autophagy 12-like, APG12-like, Apg12 (autophagy, yeast) homolog, autophagy-related protein 12
Molecular Weight 15113 DA
Gene ID 9140
UniProt O94817
Research Area Apoptosis/Necrosis, Autophagy, Cell Structure
Pathways Autophagy
Application Notes WB = 1:200-2000, IHC (p) = 1:50-200, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ATG12 antibody (Autophagy Related 12) (ABIN387794) Western blot analysis of anti-APG12 Monoclonal Antibody (ABIN387794) by APG12 recombi...
Immunohistochemistry (IHC) image for anti-ATG12 antibody (Autophagy Related 12) (ABIN387794) anti-Autophagy Related 12 (ATG12) antibody (Image 2)
Product cited in: Sanchez, Penfornis, Oskowitz, Boonjindasup, Cai, Dhule, Rowan, Kelekar, Krause, Pochampally: "Activation of autophagy in mesenchymal stem cells provides tumor stromal support." in: Carcinogenesis, Vol. 32, Issue 7, pp. 964-72, 2011 (PubMed).

Background publications Xia, Zhang, Chen, Zhang, Liu, Jin, Ma, Ma, Yuan: "Control of basal autophagy by calpain1 mediated cleavage of ATG5." in: Autophagy, Vol. 6, Issue 1, pp. 61-6, 2010 (PubMed).

Kang, Kim, Oh, Kim, Song, Kim, Ahn, Yoo, Lee: "Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability." in: The Journal of pathology, Vol. 217, Issue 5, pp. 702-6, 2009 (PubMed).

Lee, Finkel: "Regulation of autophagy by the p300 acetyltransferase." in: The Journal of biological chemistry, Vol. 284, Issue 10, pp. 6322-8, 2009 (PubMed).

Prigione, Cortopassi: "Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12." in: Autophagy, Vol. 3, Issue 4, pp. 377-80, 2007 (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, 2007 (PubMed).