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KDM3B antibody (Lysine (K)-Specific Demethylase 3B) (AA 25-57)

Details for Product anti-KDM3B Antibody No. ABIN387870, Supplier: Log in to see
Antigen
  • KDM3B
  • JMJD1B
  • 5830462I21Rik
  • JHDM2B
  • Jmjd1b
  • mKIAA1082
  • 5qNCA
  • C5orf7
  • NET22
  • lysine (K)-specific demethylase 3B
  • jumonji domain containing 1B
  • KDM3B lysine (K)-specific demethylase 3B
  • KDM3B
  • LOC100346181
  • kdm3b
  • Kdm3b
Epitope
AA 25-57, N-Term
19
11
7
7
6
3
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
102
48
36
7
6
5
4
4
3
3
2
2
2
2
Host
Rabbit
98
4
Clonality (Clone)
Polyclonal ()
Conjugate
This KDM3B antibody is un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
66
48
18
17
13
13
13
7
5
4
4
Options
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Immunogen This JMJD1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-57 AA from the N-terminal region of human JMJD1B.
Clone RB10782
Isotype Ig
Specificity This JMJD1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34~63 amino acids from the N-terminal region of human JMJD1B.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name JMJD1B (KDM3B Antibody Abstract)
Background Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Synonyms: JmjC domain-containing histone demethylation protein 2B, Jumonji domain-containing protein 1B, Nuclear protein 5qNCA, JMJD1B, C5orf7, JHDM2B, KIAA1082,
Molecular Weight 191611 DA
Gene ID 51780
UniProt Q7LBC6
Research Area Signaling, Protein Modifications, Cancer, Cell Cycle, Transcription Factors, Chromatin, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-KDM3B antibody (Lysine (K)-Specific Demethylase 3B) (AA 25-57) (ABIN387870) Western blot analysis of anti-JMJD1B (N-term) Pab in Ramos cell line lysate. JMJD1B (...
Background publications Lai, Godley, Joslin, Fernald, Liu, Espinosa, Zhao, Pamintuan, Till, Larson, Qian, Le Beau: "Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)." in: Genomics, Vol. 71, Issue 2, pp. 235-45, 2001 (PubMed).

Lai, Godley, Fernald, Orelli, Pamintuan, Zhao, Le Beau: "cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins." in: Genomics, Vol. 70, Issue 1, pp. 123-30, 2001 (PubMed).

Dias Neto, Correa, Verjovski-Almeida, Briones, Nagai, da Silva, Zago, Bordin, Costa, Goldman, Carvalho, Matsukuma, Baia, Simpson, Brunstein, de Oliveira, Bucher, Jongeneel, OHare, Soares, Brentani et al.: "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 7, pp. 3491-6, 2000 (PubMed).