DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (AA 389-421) antibody

Details for Product No. ABIN387907
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Antigen
Synonyms D6Ertd14e, ecat7, DNMT3L
Epitope
AA 389-421
(4), (4), (4), (3), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(50), (21), (12), (2)
Host
Rabbit
(44), (9)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(34), (20), (13), (10), (10), (10), (7), (6), (4), (3), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN387907
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This Mouse Dnmt3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-421 AA from mouse Dnmt3L.
Clone RB2393
Isotype Ig
Specificity This Mouse Dnmt3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 392~421 amino acids from the mouse Dnmt3L sequence within the last 100 aa. The antibody may recognize the human homolog (44 kDa).
Predicted Reactivity Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Dnmt3L
Background MDnmt3L (DNA methyltransferase 3L) does not appear to be catalytically active due to loss of the critical active site residues. It may function not directly as a DNA methyltransferase but rather as a regulator of methylation at imprinted loci. It is required specifically for the establishment of genomic imprints but is dispensable for their propagation. It is essential for the de novo methylation of single-copy DNA sequences. The protein is well-express in testis, thymus, ovary, and heart. mDnmt3L, which belongs to the 5-cytosine methyltransferase family, contains 1 ADD-type zinc finger.
Synonyms: DNA (cytosine-5)-methyltransferase 3-like
Molecular Weight 47992 DA
Gene ID 54427
UniProt Q9CWR8
Research Area Signaling, Protein Modifications, Cancer, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (AA 389-421) antibody Western blot analysis of Mouse Dnmt3L Antibody (ABIN387907) in Hela cell line lysates (35 µg/lane). Dnmt3l (arrow) was detected using the purified polyclonal antibody.
Background publications Bourchis, Xu, Lin et al.: "Dnmt3L and the establishment of maternal genomic imprints." in: Science (New York, N.Y.), Vol. 294, Issue 5551, pp. 2536-9, 2001 (PubMed).

Okazaki, Furuno, Kasukawa et al.: "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." in: Nature, Vol. 420, Issue 6915, pp. 563-73, 2002 (PubMed).

Hosts (44), (9)
Reactivities (50), (21), (12), (2)
Applications (34), (20), (13), (10), (10), (10), (7), (6), (4), (3), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (4), (4), (3), (3), (2), (1), (1), (1), (1), (1)
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