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DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (AA 389-421) antibody

Details for Product No. ABIN387907, Supplier: Login to see
Antigen
  • DNMT3L
  • D6Ertd14e
  • ecat7
Epitope
AA 389-421
38
35
16
15
6
6
6
3
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
135
47
16
2
Host
Rabbit
102
45
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
8
8
7
7
7
7
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
116
52
51
47
45
40
11
10
7
5
2
2
1
Supplier
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Immunogen This Mouse Dnmt3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-421 AA from mouse Dnmt3L.
Clone RB2393
Isotype Ig
Specificity This Mouse Dnmt3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 392~421 amino acids from the mouse Dnmt3L sequence within the last 100 aa. The antibody may recognize the human homolog (44 kDa).
Predicted Reactivity Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Dnmt3L (TRDMT1 Antibody Abstract)
Background MDnmt3L (DNA methyltransferase 3L) does not appear to be catalytically active due to loss of the critical active site residues. It may function not directly as a DNA methyltransferase but rather as a regulator of methylation at imprinted loci. It is required specifically for the establishment of genomic imprints but is dispensable for their propagation. It is essential for the de novo methylation of single-copy DNA sequences. The protein is well-express in testis, thymus, ovary, and heart. mDnmt3L, which belongs to the 5-cytosine methyltransferase family, contains 1 ADD-type zinc finger.
Synonyms: DNA (cytosine-5)-methyltransferase 3-like
Molecular Weight 47992 DA
Gene ID 54427
UniProt Q9CWR8
Research Area Signaling, Protein Modifications, Cancer, Cell Structure
Pathways
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (AA 389-421) antibody (ABIN387907) Western blot analysis of Mouse Dnmt3L Antibody (ABIN387907) in Hela cell line lysates...
Background publications Okazaki, Furuno, Kasukawa et al.: "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. ..." in: Nature, Vol. 420, Issue 6915, pp. 563-73, 2002 (PubMed).

Bourchis, Xu, Lin et al.: "Dnmt3L and the establishment of maternal genomic imprints." in: Science (New York, N.Y.), Vol. 294, Issue 5551, pp. 2536-9, 2001 (PubMed).