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Details for Product No. ABIN387993

SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) (C-Term), (AA 362-393) antibody

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Antigen
Synonyms 2410195B05Rik, AA617402, AW536475, PR-SET7, SET8, KMT5A, SET07, PR-Set7
Epitope
»Alternatives C-Term, AA 362-393
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN387993
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This SET07 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 362-393 AA from the C-terminal region of human SET07.
Clone RB1417
Isotype Ig
Specificity This SET07 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364~393 amino acids from the C-terminal region of human SET07.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SET07
Background SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.
Synonyms: Histone-lysine N-methyltransferase, H4 lysine-20 specific, Histone H4-K20 methyltransferase, H4-K20-HMTase, SET domain-containing protein 8, PR/SET domain-containing protein 07, PR-Set7 , PR/SET07, KMT5A
Molecular Weight 42890 DA
Gene ID 387893
UniProt Q9NQR1
Research Area Signaling, Protein Modifications, Cancer, Transcription Factors, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Nishioka, Rice, Sarma et al.: "PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin." in: Molecular cell, Vol. 9, Issue 6, pp. 1201-13, 2002 (PubMed).

Alternatives for antigen "SET Domain Containing (Lysine Methyltransferase) 8 (SETD8)", type "Antibodies"
Hosts (19), (11)
Reactivities (30), (12)
Applications (28), (12), (8), (7), (3), (2), (2)
Epitopes (13), (3), (2), (2), (1), (1), (1), (1), (1)
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