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CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (AA 1-30)

Details for Product anti-CBL Antibody No. ABIN388071, Supplier: Log in to see
Antigen
  • 4732447J05Rik
  • Cbl-2
  • c-Cbl
  • cbl
  • C-CBL
  • CBL2
  • FRA11B
  • NSLL
  • RNF55
  • c-cbl-like
  • RGD1561386
  • Casitas B-lineage lymphoma
  • Cbl proto-oncogene, E3 ubiquitin protein ligase
  • Cbl
  • CBL
Alternatives
anti-Human CBL antibody for Western Blotting
Epitope
AA 1-30, N-Term
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28
25
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2
2
2
2
2
2
2
1
1
1
1
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1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
259
173
163
7
7
5
4
4
4
2
2
1
Host
Rabbit
209
38
17
1
Clonality (Clone)
Polyclonal ()
Conjugate
This CBL antibody is un-conjugated
7
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5
5
5
5
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5
5
5
4
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
179
74
68
65
57
42
19
15
9
6
5
3
3
3
1
1
1
1
Options
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Immunogen This CBLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human CBLC.
Clone RB0694
Isotype Ig
Specificity This CBLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3~33 amino acids from the N-terminal region of human Cbl-c.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Cbl (CBL Antibody Abstract)
Background CBLC proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
Synonyms: Signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, RING finger protein 57, RNF57, CBLC
Molecular Weight 52456 DA
Gene ID 23624
UniProt Q9ULV8
Research Area Ubiquitin-related antibodies, Cell Signaling, Protein Modifications, Cell Structure
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway
Application Notes IHC (p) = 1:50-100, WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (AA 1-30) (ABIN388071) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (AA 1-30) (ABIN388071) CBLC Antibody (R10) (ABIN388071) western blot analysis in CEM cell line lysates (35 µ...
Background publications Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).