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CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (AA 424-453)

Details for Product anti-CBL Antibody No. ABIN388072, Supplier: Log in to see
Antigen
  • 4732447J05Rik
  • Cbl-2
  • c-Cbl
  • cbl
  • C-CBL
  • CBL2
  • FRA11B
  • NSLL
  • RNF55
  • c-cbl-like
  • RGD1561386
Alternatives
anti-Human CBL antibody for Western Blotting
Epitope
AA 424-453, C-Term
38
32
26
23
17
5
5
4
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
227
133
127
6
4
4
4
1
1
1
Host
Rabbit
189
33
9
1
Clonality (Clone)
Polyclonal ()
Conjugate
This CBL antibody is un-conjugated
7
6
6
5
5
5
5
5
5
5
5
5
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
149
64
59
56
49
29
18
13
5
5
4
3
3
1
1
1
1
1
Supplier
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Immunogen This CBLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 424-453 AA from the C-terminal region of human CBLC.
Clone RB0696
Isotype Ig
Specificity This CBLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172~202 amino acids from the C-terminal region of human Cbl-c.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Cbl (CBL Antibody Abstract)
Background Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
Synonyms: Signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, RING finger protein 57, RNF57, CBLC
Molecular Weight 52456 DA
Gene ID 23624
UniProt Q9ULV8
Research Area Ubiquitin-related antibodies, Cell Signaling, Protein Modifications, Cell Structure
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway
Application Notes IHC (p) = 1:50-100, WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (AA 424-453) (ABIN388072) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (AA 424-453) (ABIN388072) CBLC Antibody (R439) (ABIN388072) western blot analysis in K562 cell line lysates (35...
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).