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Details for Product No. ABIN388588

UV Radiation Resistance Associated Gene (UVRAG) (AA 120-152), (Leu133) antibody

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Antigen
Synonyms DHTX, VPS38, p63, Uvrag1, Uvragl, AI648770, BB124205, 9530039D02Rik, CG6116, Dmel\\CG6116, UVRAG, zgc:56164, uvrag, MGC81810, MGC131135
Epitope
»Alternatives AA 120-152, Leu133
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN388588
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-152 AA from human UVRAG.
Clone RB10846
Isotype Ig
Specificity This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128~157 amino acids from the N-term (around L133) of human UVRAG.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name UVRAG
Background UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
Synonyms: UV radiation resistance-associated gene protein, p63
Molecular Weight 78151 DA
Gene ID 7405
UniProt Q9P2Y5
Research Area Cell Signaling, Cancer, Autophagy, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IF : Tested,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Perelman, Dafni, Naiman et al.: "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus." in: Genomics, Vol. 41, Issue 3, pp. 397-405, 1997 (PubMed).

Ionov, Nowak, Perucho et al.: "Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability." in: Oncogene, Vol. 23, Issue 3, pp. 639-45, 2004 (PubMed).

Liang, Feng, Ku et al.: "Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG." in: Nature cell biology, Vol. 8, Issue 7, pp. 688-99, 2006 (PubMed).

Alternatives for antigen "UV Radiation Resistance Associated Gene (UVRAG)", type "Antibodies"
Hosts (28), (5)
Reactivities (33), (24), (16), (13), (1), (1), (1), (1)
Applications (23), (10), (9), (8), (8), (6), (4), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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