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UVRAG antibody (UV Radiation Resistance Associated Gene) (AA 120-152)

Details for Product anti-UVRAG Antibody No. ABIN388588, Supplier: Log in to see
Antigen
  • CG6116
  • Dmel\\CG6116
  • UVRAG
  • Uvrag1
  • zgc:56164
  • uvrag
  • MGC81810
  • MGC131135
  • DHTX
  • VPS38
  • p63
  • 9530039D02Rik
  • AI648770
  • BB124205
  • Uvragl
Epitope
AA 120-152, Leu133
29
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
91
66
56
1
Host
Rabbit
83
8
Clonality (Clone)
Polyclonal ()
Conjugate
This UVRAG antibody is un-conjugated
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
72
17
13
12
11
5
5
2
1
Supplier
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Immunogen This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-152 AA from human UVRAG.
Clone RB10846
Isotype Ig
Specificity This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128~157 amino acids from the N-term (around L133) of human UVRAG.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name UVRAG (UVRAG Antibody Abstract)
Background UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
Synonyms: UV radiation resistance-associated gene protein, p63
Molecular Weight 78151 DA
Gene ID 7405
UniProt Q9P2Y5
Research Area Cell Signaling, Cancer, Autophagy, Cell Structure
Pathways
Application Notes WB = 1:1000, IF = Tested, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-UVRAG antibody (UV Radiation Resistance Associated Gene) (AA 120-152) (ABIN388588) Western blot analysis of anti-hUVRAG (Center) Pab (ABIN388588) in mouse liver tissue ...
Immunohistochemistry (IHC) image for anti-UVRAG antibody (UV Radiation Resistance Associated Gene) (AA 120-152) (ABIN388588) Immunofluorescence staining of Autophagy UVRAG antibody (ABIN388588) on Methanol-fixe...
Immunohistochemistry (IHC) image for anti-UVRAG antibody (UV Radiation Resistance Associated Gene) (AA 120-152) (ABIN388588) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with hUVRAG...
Background publications Liang, Feng, Ku et al.: "Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG." in: Nature cell biology, Vol. 8, Issue 7, pp. 688-99, 2006 (PubMed).

Ionov, Nowak, Perucho et al.: "Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability." in: Oncogene, Vol. 23, Issue 3, pp. 639-45, 2004 (PubMed).

Perelman, Dafni, Naiman et al.: "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus." in: Genomics, Vol. 41, Issue 3, pp. 397-405, 1997 (PubMed).

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