Chromobox Homolog 8 (CBX8) (C-Term), (AA 306-337) antibody

Details for Product No. ABIN389089
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Antigen
Synonyms PC3, RC1, Pc3, cbx8, MGC147589
Epitope
C-Term, AA 306-337
(6), (4), (4), (2), (2), (2), (1), (1)
Reactivity
Human, Mouse (Murine)
(51), (21), (18), (15), (15), (12), (2), (2), (1), (1)
Host
Rabbit
(32), (15), (5)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(42), (17), (10), (10), (7), (4), (2), (2)
Pubmed 3 references available
Catalog no. ABIN389089
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This CBX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-337 AA from the C-terminal region of human CBX8.
Clone RB2937
Isotype Ig
Specificity This CBX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314~344 amino acids from the C-terminal region of human CBX8.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CBX8
Background Chromobox homolog 8 (CBX8 or Pc3) is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators and thus are essential for proper development. Changes in expression of PcG proteins have been associated with cancer. CBX8 is involved in maintaining the transcriptionally repressive state of genes. It modifies chromatin, rendering it heritably changed in its expressibility. Structurally, CBX4 contains 1 chromo domain, which is 40 to 50 amino acids long.
Synonyms: Chromobox protein homolog 8, Polycomb 3 homolog, Pc3, HPC3, Rectachrome 1
Molecular Weight 43437 DA
Gene ID 57332
UniProt Q9HC52
Research Area Protein Modifications, Cancer, Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Chromobox Homolog 8 (CBX8) (C-Term), (AA 306-337) antibody The anti-CBX8 C-term Pab (ABIN389089) is used in Western blot to detect CBX8 in mouse kidney tissue lysate.
anti-Chromobox Homolog 8 (CBX8) (C-Term), (AA 306-337) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
anti-Chromobox Homolog 8 (CBX8) (C-Term), (AA 306-337) antibody (3) CBX8 Antibody (Y321) (ABIN389089) western blot analysis in Hela cell line lysates (35 µg/lane).This demonstrates the CBX8 antibody detected the CBX8 protein (arrow).
Background publications Bárdos, Saurin, Tissot et al.: "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties." in: The Journal of biological chemistry, Vol. 275, Issue 37, pp. 28785-92, 2000 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Hosts (32), (15), (5)
Reactivities (51), (21), (18), (15), (15), (12), (2), (2), (1), (1)
Applications (42), (17), (10), (10), (7), (4), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (4), (4), (2), (2), (2), (1), (1)
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