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LGR5 antibody (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5) (AA 443-473)

Details for Product anti-LGR5 Antibody No. ABIN389219, Supplier: Login to see
Antigen
  • lgr5-a
  • lgr5a
  • FEX
  • Gpr49
  • GPR49
  • GPR67
  • GRP49
  • HG38
Epitope
AA 443-473, Center
21
10
8
5
5
4
4
4
4
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Human
118
31
6
Host
Rabbit
73
46
2
Clonality (Clone)
Polyclonal ()
Conjugate
This LGR5 antibody is un-conjugated
2
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
76
51
36
29
27
17
17
3
3
2
2
2
1
1
Supplier
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Immunogen This LGR5 (GPR49) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-473 AA from the Central region of human LGR5 (GPR49).
Clone RB14555
Isotype Ig
Specificity This LGR5 (GPR49) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 451~480 amino acids from the center region of human LGR5/GPR49.
Predicted Reactivity Cow (Bovine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name LGR5 (GPR49) (LGR5 Antibody Abstract)
Background LGR5/GPR49 is an orphan receptor. It may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues.
Synonyms: Leucine-rich repeat-containing G-protein coupled receptor 5 [Precursor], Orphan G-protein coupled receptor HG38, G-protein coupled receptor 49, G-protein coupled receptor 67, LGR5, GPR49, GPR67
Molecular Weight 99867 DA
Gene ID 8549
UniProt O75473
Research Area Stem Cells, Cell Signaling, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-LGR5 antibody (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5) (AA 443-473) (ABIN389219) Western blot analysis of anti-LGR5/GPR49 Antibody (Center) (ABIN389219) in K562 cell ...
Immunohistochemistry (IHC) image for anti-LGR5 antibody (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5) (AA 443-473) (ABIN389219) Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antib...
Western Blotting (WB) image for anti-LGR5 antibody (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5) (AA 443-473) (ABIN389219) LGR5/GPR49 Antibody (Center) (ABIN389219) western blot analysis in HepG2 cell line ly...
Product cited in: Judah, Rudkouskaya, Wilson et al.: "Multiple roles of integrin-linked kinase in epidermal development, maturation and pigmentation revealed by molecular profiling." in: PLoS ONE, Vol. 7, Issue 5, pp. e36704, 2012 (PubMed).

Walker, Zhang, Odorizzi et al.: "LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines." in: PLoS ONE, Vol. 6, Issue 7, pp. e22733, 2011 (PubMed).

Background publications Barker, van Es, Kuipers et al.: "Identification of stem cells in small intestine and colon by marker gene Lgr5." in: Nature, Vol. 449, Issue 7165, pp. 1003-7, 2007 (PubMed).