Amyloid beta (A4) Precursor Protein (APP) (pSer730) antibody

Details for Product No. ABIN389515
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Antigen
Synonyms
APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Abpp, Adap, ... show more
APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10, wu:fk65e12, zgc:85740 show less
Epitope
pSer730
(115), (87), (32), (30), (24), (13), (13), (10), (10), (10), (9), (8), (7), (7), (6), (5), (5), (5), (5), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(697), (355), (294), (212), (202), (196), (190), (71), (13), (13), (4), (2), (1), (1), (1), (1)
Host
Rabbit
(494), (197), (41), (6), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(29), (26), (24), (17), (17), (17), (17), (17), (17), (17), (17), (9), (5), (5), (4), (4), (4), (4), (2), (2)
Application
Western Blotting (WB)
(469), (245), (177), (159), (156), (61), (48), (42), (29), (23), (7), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 400 μL
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Catalog No. ABIN389515
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Immunogen This APP Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S730 of human APP.
Clone RB6972
Isotype Ig
Specificity This Phospho-APP-S730 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S730 of human APP.
Predicted Reactivity Mouse (Murine),Pig (Porcine),Monkey,Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name APP
Background APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Synonyms: Amyloid beta A4 protein [Precursor], APP, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA4, APP, A4, AD1,
Molecular Weight 86943 DA
Gene ID 351
UniProt P05067
Research Area Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure, Transcription Factors, Neurology
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.33 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Amyloid beta (A4) Precursor Protein (APP) (pSer730) antibody The anti-Phospho-APP-S730 Pab (ABIN389515) is used in Western blot to detect Phospho-APP-S730 in Jurkat tissue lysate.
Background publications Murakami, Irie, Morimoto et al.: "Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 46179-87, 2003 (PubMed).

Lleó, Berezovska, Ramdya et al.: "Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression." in: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 47370-5, 2003 (PubMed).

Kim, Kim, Lee et al.: "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 904-9, 2003 (PubMed).

Zhou, Su, Li et al.: "Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho." in: Science (New York, N.Y.), Vol. 302, Issue 5648, pp. 1215-7, 2003 (PubMed).

Borroni, Colciaghi, Caltagirone et al.: "Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: a 2-year follow-up study." in: Archives of neurology, Vol. 60, Issue 12, pp. 1740-4, 2003 (PubMed).

Validation Images
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