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Tyrosine-protein kinase ABL1 (ABL1) (pTyr204) antibody

Details for Product No. ABIN389865, Supplier: Log in to see
Antigen
Epitope
pTyr204
51
49
40
30
29
27
25
23
17
15
15
15
14
14
14
14
14
14
14
14
12
9
9
8
8
7
7
7
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
590
339
271
9
3
1
Host
Rabbit
587
23
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
32
31
30
30
16
16
16
15
15
15
15
15
15
15
15
1
Application
Dot Blot (DB), Immunofluorescence (IF)
343
192
180
172
95
61
44
21
20
6
2
2
1
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Immunogen This ABL Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y204 of human ABL.
Clone RB7973
Isotype Ig
Specificity This Phospho-ABL-Y204 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y204 of human ABL.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ABL
Background ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Synonyms: Proto-oncogene tyrosine-protein kinase ABL1, p150, c-ABL, Abelson murine leukemia viral oncogene homolog 1, ABL1, ABL, JTK7
Molecular Weight 122873 DA
Gene ID 25
UniProt P00519
Research Area Apoptosis/Necrosis, Cancer, Cell Cycle, Phospho-specific antibodies, Cell Structure
Application Notes DB = 1:500, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.37 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Dot Blot (DB) image for anti-Tyrosine-protein kinase ABL1 (ABL1) (pTyr204) antibody (ABIN389865) Dot blot analysis of anti-ABL-pY204 Pab (ABIN389865) on nitrocellulose membrane. 50 ...
Background publications Barnes, McIntosh, Whetton, Daley, Bentley, Baldwin: "Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation." in: Oncogene, Vol. 24, Issue 20, pp. 3257-67, 2005 (PubMed).

Kim, Cho, Yoon, Park, Kim, Lee, Chun, Kim, Lee et al.: "Interpretation of submicroscopic deletions of the BCR or ABL gene should not depend on extra signal-FISH: problems in interpretation of submicroscopic deletion of the BCR or ABL gene with extra ..." in: Genes, chromosomes & cancer, Vol. 43, Issue 1, pp. 37-44, 2005 (PubMed).

Aichberger, Mayerhofer, Krauth, Skvara, Florian, Sonneck, Akgul, Derdak, Pickl, Wacheck, Selzer, Monia, Moriggl, Valent, Sillaber: "Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides." in: Blood, Vol. 105, Issue 8, pp. 3303-11, 2005 (PubMed).

Wei, Li, Liu: "Insights into selective activation of p53 DNA binding by c-Abl." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 12271-8, 2005 (PubMed).

Robinson, Martineau, Harris, Barber, Jalali, Moorman, Strefford, Broadfield, Cheung, Harrison: "Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemia." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 19, Issue 4, pp. 564-71, 2005 (PubMed).