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DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (pSer154) antibody

Details for Product No. ABIN389917, Supplier: Login to see
Antigen
  • cb1075
  • cb983
  • dmnt1
  • fb05h01
  • mta
  • wu:fb05h01
  • ADCADN
  • AIM
  • CXXC9
  • DNMT
  • HSN1E
  • MCMT
  • DDM2
  • DECREASED DNA METHYLATION 2
  • DMT01
  • DMT1
  • DNA METHYLTRANSFERASE
  • DNA METHYLTRANSFERASE 01
  • DNA METHYLTRANSFERASE 1
  • MET2
  • METHYLTRANSFERASE 2
  • METHYLTRANSFERASE I
  • METI
  • methyltransferase 1
  • Cxxc9
  • Dnmt
  • Dnmt1o
  • MTase
  • Met-1
  • Met1
  • MommeD2
  • m.MmuI
Epitope
pSer154
59
42
35
28
22
21
20
19
13
13
13
12
10
9
9
7
7
7
6
5
5
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
387
110
41
40
36
5
5
5
3
2
1
1
1
1
1
1
Host
Rabbit
251
111
20
8
3
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
23
23
20
18
18
18
5
5
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
Application
Dot Blot (DB)
256
130
104
97
82
71
46
39
26
22
10
7
2
1
1
Supplier
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Immunogen This Dnmt1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S154 of human Dnmt1.
Clone RB18429
Isotype Ig
Specificity This Phospho-Dnmt1-pS154 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S154 of human Dnmt1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Dnmt1 (DNMT1 Antibody Abstract)
Background DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities.
Synonyms: DNA (cytosine-5)-methyltransferase 1, Dnmt1, DNA methyltransferase HsaI, DNA MTase HsaI, MCMT, M.HsaI, AIM, DNMT
Molecular Weight 183165 DA
Gene ID 1786
UniProt P26358
Research Area Signaling, Protein Modifications, Phospho-specific antibodies
Pathways
Application Notes DB = 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.32 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Dot Blot (DB) image for anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (pSer154) antibody (ABIN389917) Dot blot analysis of anti-Phospho-Dnmt1-pS154 Antibody (ABIN389917) on nitrocellulose...
Background publications Liao, Siu, Chan et al.: "Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis." in: International journal of cancer. Journal international du cancer, Vol. 123, Issue 2, pp. 296-302, 2008 (PubMed).

Dion, Lin, Hubert et al.: "Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline." in: Human molecular genetics, Vol. 17, Issue 9, pp. 1306-17, 2008 (PubMed).