DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (pSer154) antibody

Details for Product No. ABIN389917
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Antigen
Synonyms
cb1075, cb983, dmnt1, fb05h01, mta, wu:fb05h01, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, DDM2, DECREASED DNA METHYLATION 2, DMT01, DMT1, DNA METHYLTRANSFERASE, DNA METHYLTRANSFERASE 01, DNA METHYLTRANSF ... show more
cb1075, cb983, dmnt1, fb05h01, mta, wu:fb05h01, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, DDM2, DECREASED DNA METHYLATION 2, DMT01, DMT1, DNA METHYLTRANSFERASE, DNA METHYLTRANSFERASE 01, DNA METHYLTRANSFERASE 1, MET2, METHYLTRANSFERASE 2, METHYLTRANSFERASE I, METI, methyltransferase 1, Cxxc9, Dnmt, Dnmt1o, MTase, Met-1, Met1, MommeD2, m.MmuI show less
Epitope
pSer154
(23), (20), (17), (16), (13), (13), (12), (12), (12), (12), (10), (9), (7), (6), (6), (6), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(230), (64), (57), (52), (42), (34), (24), (6), (2), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(171), (51), (10), (7), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(13), (13), (11), (8), (8), (8), (5), (5), (5), (5), (5), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Dot Blot (DB)
(149), (65), (58), (50), (45), (42), (40), (38), (12), (12), (7), (7), (6), (1), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN389917
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Immunogen This Dnmt1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S154 of human Dnmt1.
Clone RB18429
Isotype Ig
Specificity This Phospho-Dnmt1-pS154 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S154 of human Dnmt1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Dnmt1
Background DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities.
Synonyms: DNA (cytosine-5)-methyltransferase 1, Dnmt1, DNA methyltransferase HsaI, DNA MTase HsaI, MCMT, M.HsaI, AIM, DNMT
Molecular Weight 183165 DA
Gene ID 1786
UniProt P26358
Research Area Signaling, Protein Modifications, Phospho-specific antibodies
Application Notes DB = 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.32 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (pSer154) antibody Dot blot analysis of anti-Phospho-Dnmt1-pS154 Antibody (ABIN389917) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL.
Background publications Dion, Lin, Hubert et al.: "Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline." in: Human molecular genetics, Vol. 17, Issue 9, pp. 1306-17, 2008 (PubMed).

Liao, Siu, Chan et al.: "Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis." in: International journal of cancer. Journal international du cancer, Vol. 123, Issue 2, pp. 296-302, 2008 (PubMed).

Validation Images
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