ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) (C-Term), (AA 1038-1067) antibody

Details for Product No. ABIN390059
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Antigen
Synonyms BSEP, PGY4, SPGP, ABC16, BRIC2, PFIC2, PFIC-2, Bsep, Lith1, Spgp, BSEP/SPGP, ABCB11
Epitope
C-Term, AA 1038-1067
(3), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(36), (27), (26)
Host
Rabbit
(34), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(20), (18), (11), (9), (2), (1)
Pubmed 1 reference available
Catalog no. ABIN390059
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This ABCB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1038-1067 AA from the C-terminal region of human ABCB11.
Clone RB2211
Isotype Ig
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ABCB11
Background ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
Molecular Weight 146392 Da
Gene ID 8647
UniProt O95342
Research Area Cell Structure
Application Notes Suggested dilutions:
WB = 1:1000, IHC = 1:50-100
Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Expiry Date 6 months
Supplier Images
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) (C-Term), (AA 1038-1067) antibody The anti-ABCB11 C-term Pab (ABIN390059) is used in Western blot to detect ABCB11 in mouse liver tissue lysate.
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) (C-Term), (AA 1038-1067) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Strautnieks, Bull, Knisely et al.: "A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis." in: Nature genetics, Vol. 20, Issue 3, pp. 233-8, 1998 (PubMed).

Hosts (34), (3)
Reactivities (36), (27), (26)
Applications (20), (18), (11), (9), (2), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (3), (1), (1), (1), (1)
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