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Details for Product No. ABIN390059

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) (C-Term), (AA 1038-1067) antibody

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Antigen
Synonyms BSEP, PGY4, SPGP, ABC16, BRIC2, PFIC2, PFIC-2, Bsep, Lith1, Spgp, BSEP/SPGP, ABCB11
Epitope
»Alternatives C-Term, AA 1038-1067
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN390059
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This ABCB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1038-1067 AA from the C-terminal region of human ABCB11.
Clone RB2211
Isotype Ig
Specificity This ABCB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1045~1075 amino acids from the C-terminal region of human ABCB11.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ABCB11
Background ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
Molecular Weight 146392 DA
Gene ID 8647
UniProt O95342
Research Area Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Strautnieks, Bull, Knisely et al.: "A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis." in: Nature genetics, Vol. 20, Issue 3, pp. 233-8, 1998 (PubMed).

Alternatives for antigen "ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11)", type "Antibodies"
Hosts (36), (3)
Reactivities (38), (29), (26)
Applications (20), (20), (11), (9), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (4), (1), (1), (1), (1), (1)
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