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Details for Product No. ABIN390249

Poly (ADP-Ribose) Polymerase Family, Member 6 (PARP6) (C-Term), (AA 553-583) antibody

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Antigen
Synonyms ARTD17, PARP-6-B1, PARP-6-C, pART17, 1700119G14Rik, 2310028P13Rik, 3110038K10Rik, C030013N01Rik, PARP-6, RGD1310937
Epitope
»Alternatives C-Term, AA 553-583
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN390249
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This Parp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-583 AA from the C-terminal region of human Parp6.
Clone RB14167
Isotype Ig
Specificity This Parp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541~571 amino acids from the C-terminal region of human PARP6.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Parp6
Background Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
Synonyms: Poly [ADP-ribose] polymerase 6, PARP-6, PARP6
Molecular Weight 71115 DA
Gene ID 56965
UniProt Q2NL67
Research Area Translation Factors, Cell Cycle, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Amé, Spenlehauer, de Murcia: "The PARP superfamily." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 26, Issue 8, pp. 882-93, 2004 (PubMed).

Alternatives for antigen "Poly (ADP-Ribose) Polymerase Family, Member 6 (PARP6)", type "Antibodies"
Hosts (23)
Reactivities (21), (4), (4), (2), (1), (1)
Applications (23), (6), (2), (1)
Epitopes (11), (4), (2), (2), (1)
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