Poly (ADP-Ribose) Polymerase Family, Member 6 (PARP6) (C-Term), (AA 553-583) antibody

Details for Product No. ABIN390249
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Antigen
Epitope
C-Term, AA 553-583
(14), (8), (6), (1)
Reactivity
Human
(29), (8), (8), (6), (1), (1)
Host
Rabbit
(29)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(29), (11), (3), (2), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN390249
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Immunogen This Parp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-583 AA from the C-terminal region of human Parp6.
Clone RB14167
Isotype Ig
Specificity This Parp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541~571 amino acids from the C-terminal region of human PARP6.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Parp6
Background Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
Synonyms: Poly [ADP-ribose] polymerase 6, PARP-6, PARP6
Molecular Weight 71115 DA
Gene ID 56965
UniProt Q2NL67
Research Area Translation Factors, Cell Cycle, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Poly (ADP-Ribose) Polymerase Family, Member 6 (PARP6) (C-Term), (AA 553-583) antibody Western blot analysis of Parp6 (arrow) using rabbit polyclonal Parp6 Antibody (C-term) (ABIN390249). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the Parp6 gene (Lane 2) (Origene Technologies).
Background publications Amé, Spenlehauer, de Murcia: "The PARP superfamily." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 26, Issue 8, pp. 882-93, 2004 (PubMed).

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