You are viewing an incomplete version of our website. Please click to reload the website as full version.

APP antibody (Amyloid beta (A4) Precursor Protein) (AA 736-770)

Details for Product anti-APP Antibody No. ABIN390283, Supplier: Log in to see
Antigen
  • aaa
  • AAA
  • abeta
  • ABETA
  • Abeta
  • abpp
  • Abpp
  • ABPP
  • ad1
  • AD1
  • Adap
  • Ag
  • APP
  • app
  • APP-like
  • APPI
  • appi
  • appl
  • APPL
  • BcDNA:GH04413
  • betaApp
  • CG7727
  • ctfgamma
  • CTFgamma
  • Cvap
  • CVAP
  • cvap
  • Dmel\\CG7727
  • E030013M08Rik
  • EG:65F1.5
  • PN-II
  • PN2
  • pn2
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
Alternatives
anti-Human APP antibody for Enzyme Immunoassay
Epitope
AA 736-770, C-Term
108
103
51
35
26
25
18
17
17
15
14
14
14
13
12
11
10
8
7
6
6
6
5
5
5
5
5
5
5
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
813
296
277
27
12
9
6
6
4
3
2
2
1
1
1
1
Host
Rabbit
566
227
46
4
2
Clonality (Clone)
Polyclonal ()
Conjugate
This APP antibody is un-conjugated
48
37
35
13
13
13
13
12
12
12
12
12
12
11
11
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
567
331
233
135
133
77
52
27
26
20
15
10
9
8
6
3
2
2
2
2
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 736-770 AA from the C-terminal region of human APP.
Clone RB05013-05014
Isotype Ig
Specificity This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human APP.
Predicted Reactivity Mouse (Murine),Pig (Porcine),Monkey,Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name APP (APP Antibody Abstract)
Background APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Synonyms: Alzheimer's disease amyloid A4 protein homolog , Soluble APP-beta, CTF-alpha, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, Gamma-CTF(59), Gamma-secretase C-terminal fragment 59), Gamma-CTF(57), (Gamma-secretase C-terminal fra
Molecular Weight 86943 DA
Gene ID 351
Research Area Apoptosis/Necrosis, Signaling, Protein Modifications, Cell Structure, Transcription Factors, Neurology
Pathways Caspase Cascade in Apoptosis, EGFR Signaling Pathway
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-APP antibody (Amyloid beta (A4) Precursor Protein) (AA 736-770) (ABIN390283) Western blot analysis of APP (arrow) using rabbit polyclonal APP Antibody (N-term) (A...
Western Blotting (WB) image for anti-APP antibody (Amyloid beta (A4) Precursor Protein) (AA 736-770) (ABIN390283) Western blot analysis of APP (arrow) using rabbit polyclonal APP Antibody (N-term) (A...
Background publications Zhou, Su, Li, Liu, Ryder, Wu, Gonzalez-DeWhitt, Gelfanova, Hale, May, Paul, Ni: "Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho." in: Science (New York, N.Y.), Vol. 302, Issue 5648, pp. 1215-7, 2003 (PubMed).

Murakami, Irie, Morimoto, Ohigashi, Shindo, Nagao, Shimizu, Shirasawa: "Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 46179-87, 2003 (PubMed).

Kim, Kim, Lee, Choi, Kim, Huh, Lee, Han, Rha: "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 904-9, 2003 (PubMed).