Amyloid beta (A4) Precursor Protein (APP) (C-Term), (AA 736-770) antibody

Details for Product No. ABIN390283
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Antigen
Synonyms
APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Abpp, Adap, ... show more
APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10, wu:fk65e12, zgc:85740 show less
Epitope
C-Term, AA 736-770
(114), (87), (32), (30), (25), (13), (13), (10), (10), (10), (9), (8), (7), (7), (6), (5), (5), (5), (5), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(697), (355), (294), (212), (202), (196), (190), (71), (13), (13), (4), (2), (1), (1), (1), (1)
Host
Rabbit
(494), (197), (41), (6), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(29), (26), (24), (17), (17), (17), (17), (17), (17), (17), (17), (9), (5), (5), (4), (4), (4), (4), (2), (2)
Application
Western Blotting (WB)
(469), (245), (177), (159), (156), (61), (48), (42), (29), (23), (7), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN390283
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Immunogen This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 736-770 AA from the C-terminal region of human APP.
Clone RB05013-05014
Isotype Ig
Specificity This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human APP.
Predicted Reactivity Mouse (Murine),Pig (Porcine),Monkey,Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name APP
Background APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Synonyms: Alzheimer's disease amyloid A4 protein homolog , Soluble APP-beta, CTF-alpha, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, Gamma-CTF(59), Gamma-secretase C-terminal fragment 59), Gamma-CTF(57), (Gamma-secretase C-terminal fra
Molecular Weight 86943 DA
Gene ID 351
Research Area Apoptosis/Necrosis, Signaling, Protein Modifications, Cell Structure, Transcription Factors, Neurology
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term), (AA 736-770) antibody Western blot analysis of APP (arrow) using rabbit polyclonal APP Antibody (N-term) (ABIN390283). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the APP gene (Lane 2) (Origene Technologies).
anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term), (AA 736-770) antibody (2) Western blot analysis of APP (arrow) using rabbit polyclonal APP Antibody (N-term) (ABIN390283). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the APP gene (Lane 2) (Origene Technologies).
Background publications Murakami, Irie, Morimoto et al.: "Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 46179-87, 2003 (PubMed).

Kim, Kim, Lee et al.: "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 904-9, 2003 (PubMed).

Zhou, Su, Li et al.: "Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho." in: Science (New York, N.Y.), Vol. 302, Issue 5648, pp. 1215-7, 2003 (PubMed).

Validation Images
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