PINK1 antibody (N-Term)

Catalog No. ABIN390369

Cited in 2+ publications. The Rabbit Polyclonal anti-PINK1 antibody (Clone RB07381) (ABIN390369) specifically detects PINK1 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for PINK1 antibody (N-Term) (ABIN390369)

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PINK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB07381

Product Details anti-PINK1 Antibody

Binding Specificity: AA 118-147, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-147 amino acids from the N-terminal region of human PINK1 (PARK6).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-PINK1 antibody (ABIN390369)

Wang, Hu, Zou, Xiang, Jiang, Botchway, Huo, Du, Fang: "The post-therapeutic effect of rapamycin in mild traumatic brain-injured rats ensuing in the upregulation of autophagy and mitophagy." in: Cell biology international, Vol. 41, Issue 9, pp. 1039-1047, (2018) (PubMed).

Zhang, Gu, Chen, Ni, Hung, Wang, Zhang, Feng, Ji: "High expression of PINK1 promotes proliferation and chemoresistance of NSCLC." in: Oncology reports, Vol. 37, Issue 4, pp. 2137-2146, (2017) (PubMed).

Target Details for PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Alternative Name: PINK1 (PARK6)

Background: Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

Molecular Weight: 62769

Gene ID: 65018

NCBI Accession: NP_115785

UniProt: Q9BXM7

Pathways: Autophagy