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MTMR4 antibody (C-Term)

MTMR4 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB0716 unconjugated
Catalog No. ABIN390777
  • Target See all MTMR4 Antibodies
    MTMR4 (Myotubularin Related Protein 4 (MTMR4))
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1155-1187, C-Term
    Reactivity
    • 37
    • 11
    • 3
    Human, Mouse
    Host
    • 36
    • 1
    Rabbit
    Clonality
    • 37
    Polyclonal
    Conjugate
    • 15
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MTMR4 antibody is un-conjugated
    Application
    • 26
    • 23
    • 10
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This MTMR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1155-1187 amino acids from the C-terminal region of human MTMR4.
    Clone
    RB0716
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Yu, He, Chen, Hao, Yang, Wang, Pan, Tang: "Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins." in: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 79-88, (2013) (PubMed).

    Yu, Pan, Qin, Chen, Xu, Chen, Tang: "MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes." in: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8454-62, (2010) (PubMed).

    Plant, Correa, Goldenberg, Bain, Batt: "The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4." in: The Biochemical journal, Vol. 419, Issue 1, pp. 57-63, (2009) (PubMed).

  • Target
    MTMR4 (Myotubularin Related Protein 4 (MTMR4))
    Alternative Name
    MTMR4 (MTMR4 Products)
    Synonyms
    zfyve11 antibody, fyve-dsp2 antibody, FYVE-DSP2 antibody, ZFYVE11 antibody, AA596759 antibody, ESTM44 antibody, mKIAA0647 antibody, myotubularin related protein 4 antibody, myotubularin related protein 4 L homeolog antibody, Mtmr4 antibody, MTMR4 antibody, mtmr4 antibody, mtmr4.L antibody
    Background
    MTMR, a member of the myotubularin family, encodes an intracellular protein of 1,195 amino acids, and shares approximately 47 % sequence identity with MTMR3, spiking to over 70 % identity in the catalytic domain and the double zinc finger (FYVE) motif. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. MTMR4 dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate.
    Molecular Weight
    133353
    Gene ID
    9110
    NCBI Accession
    NP_004678
    UniProt
    Q9NYA4
    Pathways
    Inositol Metabolic Process
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