MARK1 antibody (C-Term)

Catalog No. ABIN391220

There is 1 publication for this product available. The Rabbit Polyclonal anti-MARK1 antibody is suitable to detect MARK1 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for MARK1 antibody (C-Term) (ABIN391220)

Target: MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MARK1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB8547

Product Details anti-MARK1 Antibody

Binding Specificity: AA 671-700, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MARK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 671-700 amino acids from the C-terminal region of human MARK1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MARK1 antibody (ABIN391220)

Hezel, Gurumurthy, Granot, Swisa, Chu, Bailey, Dor, Bardeesy, Depinho: "Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2414-25, (2008) (PubMed).

Target Details for MARK1

Target: MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))

Alternative Name: MARK1

Background: MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK

Molecular Weight: 89003

Gene ID: 4139

NCBI Accession: NP_061120

UniProt: Q9P0L2

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection