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MARK1 antibody (N-Term)

MARK1 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB8545 unconjugated
Catalog No. ABIN391219
  • Target See all MARK1 Antibodies
    MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))
    Binding Specificity
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    AA 6-40, N-Term
    Reactivity
    • 62
    • 35
    • 12
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Mouse
    Host
    • 62
    • 1
    Rabbit
    Clonality
    • 63
    Polyclonal
    Conjugate
    • 26
    • 7
    • 6
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MARK1 antibody is un-conjugated
    Application
    • 49
    • 44
    • 33
    • 11
    • 7
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This MARK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-40 amino acids from the N-terminal region of human MARK1.
    Clone
    RB8545
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MARK1 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Hezel, Gurumurthy, Granot, Swisa, Chu, Bailey, Dor, Bardeesy, Depinho: "Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2414-25, (2008) (PubMed).

  • Target
    MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))
    Alternative Name
    MARK1 (MARK1 Products)
    Synonyms
    MGC80341 antibody, MARK1 antibody, AW491150 antibody, B930025N23Rik antibody, Emk3 antibody, Par-1c antibody, mKIAA1477 antibody, mPar-1c antibody, MARK antibody, Par1c antibody, MAP/microtubule affinity-regulating kinase 1 S homeolog antibody, microtubule affinity regulating kinase 1 antibody, MAP/microtubule affinity-regulating kinase 1 antibody, MAP/microtubule affinity regulating kinase 1 antibody, mark1.S antibody, MARK1 antibody, mark1 antibody, Mark1 antibody
    Background
    MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK
    Molecular Weight
    89003
    Gene ID
    4139
    NCBI Accession
    NP_061120
    UniProt
    Q9P0L2
    Pathways
    SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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