MYCN antibody (C-Term)

Catalog No. ABIN391590

Cited in 1 publication. The Rabbit Polyclonal anti-MYCN antibody (Clone RB18771) (ABIN391590) specifically detects MYCN in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for MYCN antibody (C-Term) (ABIN391590)

Target: MYCN (N-Myc Proto-Oncogene Protein (MYCN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYCN antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB18771

Product Details anti-MYCN Antibody

Binding Specificity: AA 322-351, C-Term

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MYCN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-351 amino acids from the C-terminal region of human MYCN.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MYCN antibody (ABIN391590)

Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: "p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma." in: Molecular cancer research : MCR, Vol. 13, Issue 3, pp. 584-91, (2015) (PubMed).

Target Details for MYCN

Target: MYCN (N-Myc Proto-Oncogene Protein (MYCN))

Alternative Name: MYCN

Background: MYCN is a member of the MYC family and a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of its gene is associated with a variety of tumors, most notably neuroblastomas.

Molecular Weight: 49561

Gene ID: 4613

NCBI Accession: NP_005369

UniProt: P04198