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Protein Kinase, CGMP-Dependent, Type I (PRKG1) (AA 629-660), (C-Term) antibody

Details for Product No. ABIN392536, Supplier: Log in to see
Antigen
  • prkg1
  • zgc:63955
  • Pkgi
  • cGk1
  • 1
  • PKG
  • PRKG1B
  • PRKGR1B
  • cGK
  • cGK 1
  • cGK1
  • cGKI
  • cGKI-BETA
  • cGKI-alpha
  • CGKI
  • cGKI-beta
  • AW125416
  • Gm19690
  • Prkg1b
  • Prkgr1b
  • Prkg1beta
Epitope
AA 629-660, C-Term
18
14
6
5
4
4
3
2
2
2
2
1
1
1
Reactivity
Human, Mouse (Murine)
57
15
11
4
2
1
1
1
1
Host
Rabbit
44
15
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
57
31
27
10
5
3
2
2
1
1
Supplier
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Immunogen This cGKI (cGKI beta) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 629-660 AA from the C-terminal region of human cGKI beta.
Clone RB1046
Isotype Ig
Specificity This cGKI (cGKI beta) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 644~673 amino acids from the C-terminal region of human cGKI beta.
Predicted Reactivity Cow (Bovine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name cGKI (cGKI beta) (PRKG1 Antibody Abstract)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
Synonyms: cGMP-dependent protein kinase 1, beta isozyme, PRKG1B, PRKGR1B, PRKG1
Molecular Weight 76233 DA
Gene ID 5592
UniProt P14619
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Metabolism, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Protein Kinase, CGMP-Dependent, Type I (PRKG1) (AA 629-660), (C-Term) antibody (ABIN392536) The anti-cGKI beta Pab (ABIN392536) is used in Western blot to detect cGKI beta in 29...
Immunohistochemistry (IHC) image for anti-Protein Kinase, CGMP-Dependent, Type I (PRKG1) (AA 629-660), (C-Term) antibody (ABIN392536) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: Schwappacher, Kilic, Kojonazarov et al.: "A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension." in: The Journal of biological chemistry, Vol. 288, Issue 23, pp. 16557-66, 2013 (PubMed).

Background publications Orstavik, Natarajan, Taskén et al.: "Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1)." in: Genomics, Vol. 42, Issue 2, pp. 311-8, 1997 (PubMed).