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Details for Product No. ABIN392693

Unc-51 Like Kinase 2 (C. Elegans) (ULK2) (C-Term), (AA 612-643) antibody

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Antigen
Synonyms Unc51.2, AU015340, mKIAA0623, A830085I22Rik, ATG1B, ULK2
Epitope
»Alternatives C-Term, AA 612-643
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN392693
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This ULK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 612-643 AA from the C-terminal region of human ULK2.
Clone RB03022
Isotype Ig
Specificity This ULK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 620~649 amino acids from the C-terminal sequence of human ULK2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ULK2
Background Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Two human homologs of the yeast autophagy-specific kinase exist: ULK1(APG1) and ULK2. APG1 plays a critical role in regulating key elements of the autophagy pathway. APG1 stimulates autophagy, leading to autophagy-dependent restriction of cell growth and ultimately cell apoptosis at high levels of activity, and is a negative regulator of mTOR signaling.
Synonyms: Serine/threonine-protein kinase ULK2, unc-51-like kinase 2, KIAA0623
Molecular Weight 112726 DA
Gene ID 9706
UniProt Q8IYT8
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Autophagy
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Yan, Kuroyanagi, Tomemori et al.: "Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains." in: Oncogene, Vol. 18, Issue 43, pp. 5850-9, 1999 (PubMed).

Alternatives for antigen "Unc-51 Like Kinase 2 (C. Elegans) (ULK2)", type "Antibodies"
Hosts (19), (16)
Reactivities (33), (4), (1), (1)
Applications (33), (15), (5), (4), (3), (2), (1)
Epitopes (10), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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