ULK2 antibody (N-Term)

Catalog No. ABIN392692

This Rabbit Polyclonal antibody specifically detects ULK2 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for ULK2 antibody (N-Term) (ABIN392692)

Target: ULK2 (Unc-51 Like Kinase 2 (ULK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ULK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB12561

Product Details anti-ULK2 Antibody

Binding Specificity: AA 235-264, N-Term

Predicted Reactivity: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ULK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from the N-terminal region of human ULK2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for ULK2

Target: ULK2 (Unc-51 Like Kinase 2 (ULK2))

Alternative Name: ULK2

Background: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Two human homologs of the yeast autophagy-specific kinase exist: ULK1(APG1) and ULK2. APG1 plays a critical role in regulating key elements of the autophagy pathway. APG1 stimulates autophagy, leading to autophagy-dependent restriction of cell growth and ultimately cell apoptosis at high levels of activity, and is a negative regulator of mTOR signaling.

Molecular Weight: 112694

Gene ID: 9706

NCBI Accession: NP_001136082, NP_055498

UniProt: Q8IYT8

Pathways: Regulation of Cell Size, Autophagy