SARM1 antibody

Catalog No. ABIN400726

This Mouse Monoclonal antibody specifically detects SARM1 in IP and IHC (p). It exhibits reactivity toward Human.

Quick Overview for SARM1 antibody (ABIN400726)

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SARM1 antibody is un-conjugated

Application: Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: Sarmy-1

Product Details anti-SARM1 Antibody

Specificity: This antibody recognizes Sterile Alpha And TIR Motif Containing 1 (SARM1).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: SARM, SAMD2, KIAA0524, Sterile alpha and TIR motif-containing protein 1, SAMdomain-containing protein 2, Sterile alpha and Armadillo repeat protein, Sterile alphamotif domain-containing protein 2

Purification: Protein G Chromatography.

Immunogen: Synthetic peptide - KLH conjugated.

Isotype: IgG2b

Application Details

Application Notes: Immunoprecipitation: 1/200. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 10 % Glycerol and 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for SARM1

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Alternative Name: SARM1

Background: Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular Toll/interleukin-1 receptor (TIR) domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Mal (MyD88 adaptor-like)/TIRAP (TIR domain-containing adaptor protein), Trif (TIR-domain-containing adaptor inducing interferon-beta), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). Different TLRs use different combinations of these adaptors, leading to the activation of common and unique pathways involved in the elimination of the invading microbe.Synonyms: KIAA0524, SAM domain-containing protein 2, SAMD2, SARM, Sterile alpha and Armadillo repeat protein, Sterile alpha and TIR motif-containing protein 1, Sterile alpha motif domain-containing protein 2

Gene ID: 23098

UniProt: Q6SZW1

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades