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FANCC antibody (AA 96-112)

FANCC Reactivity: Human, Chimpanzee WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN401268
  • Target See all FANCC Antibodies
    FANCC (Fanconi Anemia, Complementation Group C (FANCC))
    Binding Specificity
    • 15
    • 11
    • 8
    • 7
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 96-112
    Reactivity
    • 56
    • 6
    • 2
    Human, Chimpanzee
    Host
    • 53
    • 3
    Rabbit
    Clonality
    • 54
    • 2
    Polyclonal
    Conjugate
    • 26
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FANCC antibody is un-conjugated
    Application
    • 48
    • 26
    • 23
    • 19
    • 14
    • 13
    • 13
    • 9
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody is directed against human FANCC protein.
    Cross-Reactivity (Details)
    Species reactivity (expected):Chimpanzee (100 %).
    Species reactivity (tested):Human.
    Purification
    Affinity Purified
    Immunogen
    Synthetic peptide corresponding to amino acids 96-112 of Human FANCC
    Isotype
    IgG
    Top Product
    Discover our top product FANCC Primary Antibody
  • Application Notes
    ELISA: 1: 20,000 - 1: 80,000. Western blot: 1: 1,000 - 1: 3,000 (Expect a band approximately 63 kDa in size correspondingto FANCC in the appropriate human tissue).
    Restrictions
    For Research Use only
  • Concentration
    1.45 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Target
    FANCC (Fanconi Anemia, Complementation Group C (FANCC))
    Alternative Name
    FANCC (FANCC Products)
    Synonyms
    zgc:154105 antibody, FANCC antibody, fa3 antibody, fac antibody, facc antibody, FA3 antibody, FAC antibody, FACC antibody, BB116513 antibody, Facc antibody, Fanconi anemia complementation group C antibody, Fanconi anemia, complementation group C antibody, Fanconi anemia complementation group C L homeolog antibody, FANCC antibody, fancc antibody, fancc.L antibody, Fancc antibody
    Background
    FANCC (also called Protein FACC or Fanconi Anemia Group C protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCC may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCC belongs to the multi-subunit Fanconi Anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. FANCC is mainly found within the nucleus although some protein is localized in the cytoplasm. This protein is ubiquitously expressed. Defects in FANCC are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNAdamaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.Synonyms: FAC, FACC, Fanconi anemia group C protein
    Gene ID
    2176
    NCBI Accession
    NP_000127
    UniProt
    Q00597
    Pathways
    DNA Damage Repair
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