F11R antibody (C-Term)

Catalog No. ABIN401517

Product Details anti-F11R Antibody

Target: F11R (F11 Receptor (F11R))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This F11R antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: c-QPSARSEGEF KQTS

Specificity: This antibody detects CD321/JAM1 (C-term).

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Canine (Dog), Pig.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide from the C-Terminus of the protein sequence according to NP_058642.1. Genename: F11R

Application Details

Application Notes: Peptide ELISA: Detection Limit Dilution: 1/2000. Western blot: 0.3-2 μg/mL. Approx 38 kDa band observed in Human Peripheral BloodMononucleocyte lysates (calculated MW of 32.8 kDa according to NP_058642.1). Theobserved molecular weight corresponds to earlier findings with different antibodies fromother commercial sources.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for F11R

Target: F11R (F11 Receptor (F11R))

Alternative Name: CD321 / JAM1 (F11R Products)

Synonyms: CD321 antibody, JAM antibody, JAM1 antibody, JAMA antibody, JCAM antibody, KAT antibody, PAM-1 antibody, 9130004G24 antibody, AA638916 antibody, ESTM33 antibody, JAM-1 antibody, JAM-A antibody, Jcam antibody, Jcam1 antibody, Ly106 antibody, Jam1 antibody, F11 receptor antibody, F11R antibody, F11r antibody

Background: Junctional Adhesion Molecule 1 (JAM1) seems to plays a role in epithelial tight junction formation. It appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. JAM1 plays a role in regulating monocyte transmigration involved in integrity of the epithelial barrier. JAM1 is also involved in platelet activation.Synonyms: F11R, JAM-A, JCAM, Junctional adhesion molecule 1, Junctional adhesion molecule A, PAM1, Platelet F11 receptor, Platelet adhesion molecule 1

Gene ID: 50848

NCBI Accession: NP_058642

UniProt: Q9Y624

Pathways: Cell-Cell Junction Organization