GABRA5 antibody (Middle Region)

Catalog No. ABIN404976

The Rabbit Polyclonal anti-GABRA5 antibody (ABIN404976) specifically detects GABRA5 in WB and IHC. The antibody is reactive with Human, Rat, Mouse, Rabbit, Guinea Pig, Horse, Cow, Dog and Zebrafish (Danio rerio) samples.

Quick Overview for GABRA5 antibody (Middle Region) (ABIN404976)

Target: GABRA5 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 5 (GABRA5))

Reactivity: Human, Rat, Mouse, Rabbit, Guinea Pig, Horse, Cow, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRA5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GABRA5 Antibody

Binding Specificity: Middle Region

Purpose: GABRA5 Antibody - middle region

Sequence: GTSNTTSVSV KPSEEKTSES KKTYNSISKI DKMSRIVFPV LFGTFNLVYW

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against GABRA5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GABRA5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34984-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GABRA5

Target: GABRA5 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 5 (GABRA5))

Alternative Name: GABRA5

Background:

Targeted Subunit: alpha-5

Background Information: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Gamma-aminobutyric acid (GABA) A receptor, alpha 5

Alternative Symbols: DEE79, EIEE79

Protein Name: Gamma-aminobutyric acid receptor subunit alpha-5

Molecular Weight: 52 kDa

Gene ID: 2558

NCBI Accession: NP_000801

UniProt: P31644

Pathways: Sensory Perception of Sound, Synaptic Membrane