Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) (Middle Region) antibody

Details for Product No. ABIN404981
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Antigen
Synonyms kcnc3-A, Kv3.1, KShIIID, Kcr2-3, Kv3.3, KSHIIID, KV3.3, SCA13, kcnc1, kshiiid, kv3.3, sca13
Epitope
Middle Region
(12), (7), (7), (6), (5), (3), (2), (1), (1), (1)
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Cow (Bovine), Xenopus laevis, Human
(54), (21), (19), (12), (12), (12), (2)
Host
Rabbit
(35), (13), (11)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(50), (36), (10), (10), (7), (6), (3), (3), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN404981
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human KCNC3
Sequence YAERIGADPD DILGSNHTYF KNIPIGFWWA VVTMTTLGYG DMYPKTWSGM
Predicted Reactivity Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Bovine : 90 %
Characteristics This is a rabbit polyclonal antibody against KCNC3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name KCNC3
Background The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. KCNC3 belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.
Molecular Weight 80 kDa
Gene ID 3748
NCBI Accession NM_004977, NP_004968
UniProt Q14003
Research Area Neurology
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 757 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) (Middle Region) antibody WB Suggested Anti-KCNC3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: 293T cell lysate
Background publications Waters, Minassian, Stevanin et al.: "Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes." in: Nature genetics, Vol. 38, Issue 4, pp. 447-51, 2006 (PubMed).

Validation Images
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