KCNC3 antibody (AA 638-745)

Catalog No. ABIN7163969

This Rabbit Polyclonal antibody specifically detects KCNC3 in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for KCNC3 antibody (AA 638-745) (ABIN7163969)

Target: KCNC3 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNC3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-KCNC3 Antibody

Binding Specificity: AA 638-745

Purpose: KCNC3 Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Potassium voltage-gated channel subfamily C member 3 protein (638-745AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KCNC3

Target: KCNC3 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3))

Alternative Name: KCNC3

Background:

Background: Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484).

Aliases: Kcnc3 antibody, KCNC3_HUMAN antibody, KSHIIID antibody, KV3.3 antibody, Potassium voltage gated channel Shaw related subfamily member 3 antibody, Potassium voltage gated channel subfamily C member 3 antibody, Potassium voltage-gated channel subfamily C member 3 antibody, SCA13 antibody, Shaw related subfamily, member 3 antibody, Shaw related voltage gated potassium channel protein 3 antibody, Spinocerebellar ataxia 13 antibody, Voltage gated potassium channel protein KV3.3 antibody, Voltage gated potassium channel subunit Kv3.3 antibody, Voltage-gated potassium channel subunit Kv3.3 antibody

UniProt: Q14003