EXOSC2 antibody (Middle Region)

Catalog No. ABIN405355

This Rabbit Polyclonal antibody specifically detects EXOSC2 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio)and has been mentioned in 1 publication.

Quick Overview for EXOSC2 antibody (Middle Region) (ABIN405355)

Target: EXOSC2 (Exosome Component 2 (EXOSC2))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EXOSC2 Antibody

Binding Specificity: Middle Region

Sequence: AEVQAVFSDG AVSLHTRSLK YGKLGQGVLV QVSPSLVKRQ KTHFHDLPCG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against EXOSC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human EXOSC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 293 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-EXOSC2 antibody (ABIN405355)

van Dijk, Schilders, Pruijn: "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways." in: RNA (New York, N.Y.), Vol. 13, Issue 7, pp. 1027-35, (2007) (PubMed).

Target Details for EXOSC2

Target: EXOSC2 (Exosome Component 2 (EXOSC2))

Alternative Name: EXOSC2

Background: EXOSC2 belongs to the exosome, a RNA-processing complex, which is at least involved in the 3' processing of the 7S pre-rRNA to the mature 5.8S rRNA. It exhibits a 3'-5' exoribonuclease activity.
Alias Symbols: RRP4, Rrp4p, hRrp4p, p7
Protein Interaction Partner: GPX1, ST6GALNAC1, MRPL48, EXOSC7, RNF8, GALNT13, ZNF408, AICDA, METTL22, UBC, UPF1, MDC1, BARD1, EXOSC5, EXOSC4, EXOSC3, DEK, RAN, EXOSC9, DIS3L, DIS3, UBD, CAND1, HDGF, MEPCE, SKIV2L2, EXOSC6, KHSRP, MPP6, EXOSC8, UPF3A, UPF2,
Protein Size: 293

Molecular Weight: 32 kDa

Gene ID: 23404

NCBI Accession: NM_014285, NP_055100

UniProt: Q13868

Pathways: SARS-CoV-2 Protein Interactome