ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2) (N-Term) antibody

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Antigen
Synonyms
A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS, 8430408C20Rik, AI385560, ATP6a2, AW489264, Atp6n1d, Atp6n2, C76904, ISF, SHIF, Stv1, TJ6s, Tj6, V-ATPase 116 kDa, V-ATPa ... show more
A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS, 8430408C20Rik, AI385560, ATP6a2, AW489264, Atp6n1d, Atp6n2, C76904, ISF, SHIF, Stv1, TJ6s, Tj6, V-ATPase 116 kDa, V-ATPase a2, Cc1-3, J6b7, atp6v0a2, si:ch211-199i18.4 show less
Epitope
N-Term
(3), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio)
(15), (5), (5), (2)
Host
Rabbit
(14), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(13), (4), (2), (1), (1)
Pubmed 1 reference available
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Immunogen Synthetic peptide directed towards the N terminal of human ATP6V0A2
Blocking Peptide Blocking peptide for this product available: ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2) (N-Term) peptide (ABIN973625)
Sequence INRADIPLPE GEASPPAPPL KQVLEMQEQL QKLEVELREV TKNKEKLRKN
Predicted Reactivity Human : 100 %, Rat : 100 %, Dog : 90 %, Horse : 90 %, Pig : 90 %, Chicken : 70 %
Characteristics This is a rabbit polyclonal antibody against ATP6V0A2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ATP6V0A2 (ATP6V0A2 Antibody Abstract)
Background The multisubunit vacuolar-type proton pump (H(+)-ATPase or V-ATPase) is essential for acidification of diverse cellular components, including endosomes, lysosomes, clathrin-coated vesicles, secretory vesicles, and chromaffin granules, and it is found at high density in the plasma membrane of certain specialized cells. H(+)-ATPases are comprised of a peripheral V(1) domain and an integral membrane V(0) domain, ATP6V0A2 is a component of the V(0) domain.The multisubunit vacuolar-type proton pump (H(+)-ATPase or V-ATPase) is essential for acidification of diverse cellular components, including endosomes, lysosomes, clathrin-coated vesicles, secretory vesicles, and chromaffin granules, and it is found at high density in the plasma membrane of certain specialized cells. H(+)-ATPases are comprised of a peripheral V(1) domain and an integral membrane V(0) domain, ATP6V0A2 is a component of the V(0) domain (Smith et al., 2003 [PubMed 14580332]).
Molecular Weight 98 kDa
Gene ID 23545
NCBI Accession NM_012463, NP_036595
UniProt Q9Y487
Research Area Signaling, Metabolism
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 856 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2) (N-Term) antibody (ABIN405464) anti-ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2) (N-Term) antibody
Immunohistochemistry (IHC) image for anti-ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2) (N-Term) antibody (ABIN405464) anti-ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2) (N-Term) antibody (Image 2)
Background publications Kornak, Reynders, Dimopoulou et al.: "Impaired glycosylation and cutis laxa caused by mutations in the vesicular H+-ATPase subunit ATP6V0A2." in: Nature genetics, Vol. 40, Issue 1, pp. 32-4, 2007 (PubMed).

Catalog No. ABIN405464
$289.00
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