ATP6V0A2 antibody (Internal Region)

Catalog No. ABIN6260132

Product Details anti-ATP6V0A2 Antibody

Target: ATP6V0A2 (ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP6V0A2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: ATP6V0A2 Antibody detects endogenous levels of total ATP6V0A2.

Predicted Reactivity: Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ATP6V0A2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ATP6V0A2

Target: ATP6V0A2 (ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2))

Alternative Name: ATP6V0A2 (ATP6V0A2 Products)

Synonyms: A2 antibody, ARCL antibody, ARCL2A antibody, ATP6A2 antibody, ATP6N1D antibody, J6B7 antibody, RTF antibody, STV1 antibody, TJ6 antibody, TJ6M antibody, TJ6S antibody, VPH1 antibody, WSS antibody, 8430408C20Rik antibody, AI385560 antibody, ATP6a2 antibody, AW489264 antibody, Atp6n1d antibody, Atp6n2 antibody, C76904 antibody, ISF antibody, SHIF antibody, Stv1 antibody, TJ6s antibody, Tj6 antibody, V-ATPase 116 kDa antibody, V-ATPase a2 antibody, Cc1-3 antibody, J6b7 antibody, atp6v0a2 antibody, si:ch211-199i18.4 antibody, si:ch211-106a19.2 antibody, ATPase H+ transporting V0 subunit a2 antibody, ATPase, H+ transporting, lysosomal V0 subunit A2 antibody, ATPase, H+ transporting, lysosomal V0 subunit a2a antibody, ATPase, H+ transporting, lysosomal V0 subunit a2b antibody, ATP6V0A2 antibody, Atp6v0a2 antibody, atp6v0a2a antibody, atp6v0a2b antibody

Background:

Description: Part of the proton channel of V-ATPases. Essential component of the endosomal  pH -sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi  pH . In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).

Gene: ATP6V0A2

Molecular Weight: 98 kDa

Gene ID: 23545

UniProt: Q9Y487

Pathways: Transition Metal Ion Homeostasis, Proton Transport