Ring Finger Protein 19A (RNF19A) (N-Term) antibody

Details for Product No. ABIN405531
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Antigen
Synonyms RNF19, RNF19A, AA032313, Dorfin, Rnf19, UIP117, Ubce7ip2, XYbp
Epitope
N-Term
(9), (7), (6), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Pig (Porcine), Human
(40), (20), (13), (13), (13), (12)
Host
Rabbit
(34), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(27), (22), (10), (8), (4), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN405531
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human RNF19A
Sequence IFSTNTSSDN GLTSISKQIG DFIECPLCLL RHSKDRFPDI MTCHHRSCVD
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Guinea pig : 90 %, Rat : 90 %
Characteristics This is a rabbit polyclonal antibody against RNF19A. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name RNF19A
Background RNF19A contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB.The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.
Molecular Weight 91 kDa
Gene ID 25897
NCBI Accession NM_015435, NP_056250
UniProt Q9NV58
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 838 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Ishigaki, Niwa, Yamada et al.: "Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity." in: Neurobiology of disease, Vol. 25, Issue 2, pp. 331-41, 2007 (PubMed).

Validation Images
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