Desmocollin 3 (DSC3) (N-Term) antibody

Details for Product No. ABIN405727
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Antigen
Synonyms dsc3, MGC85083, CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP, 5430426I24Rik
Epitope
N-Term
(9), (8), (8), (2), (2), (2), (1)
Reactivity
Rat (Rattus), Mouse (Murine), Cow (Bovine), Dog (Canine), Human
(48), (23), (18), (17), (17)
Host
Rabbit
(30), (18), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(36), (17), (16), (10), (9), (8), (5), (4), (3)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN405727
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human DSC3
Sequence MQENSLGPFP LFLQQVESDA AQNYTVFYSI SGRGVDKEPL NLFYIERDTG
Predicted Reactivity Bovine : 100 %, Human : 100 %, Dog : 90 %, Rat : 90 %, Mouse : 80 %
Characteristics This is a rabbit polyclonal antibody against DSC3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name DSC3
Background DSC3 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.
Molecular Weight 85 kDa
Gene ID 1825
NCBI Accession NM_001941, NP_001932
UniProt Q14574
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 896 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Desmocollin 3 (DSC3) (N-Term) antibody WB Suggested Anti-DSC3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate
Background publications Wang, Liu, Wang et al.: "Altered expression of desmocollin 3, desmoglein 3, and beta-catenin in oral squamous cell carcinoma: correlation with lymph node metastasis and cell proliferation." in: Virchows Archiv : an international journal of pathology, Vol. 451, Issue 5, pp. 959-66, 2007 (PubMed).

Validation Images
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