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Protocadherin alpha 12 (PCDHA12) (N-Term) antibody

Details for Product No. ABIN406045
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Antigen
Synonyms CNRv12, PCDHA12, PCDH-ALPHA12, Cnr5, Crnr5, Pcdha13, Pcdha11, rCNRv12
Epitope
N-Term
(7), (7), (2), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine), Dog (Canine), Cow (Bovine), Human
(31)
Host
Rabbit
(28), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(16), (15), (14), (9), (6), (4), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN406045
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human PCDHA12
Sequence EVIVDRPLQVFHVDVEVKDINDNPPVFREREQKVPVSESA PLDSHFPLEG
Predicted Reactivity Dog : 100 %, Horse : 80 %, Mouse : 80 %, Rat : 70 %
Characteristics This is a rabbit polyclonal antibody against PCDHA12. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PCDHA12
Background PCDHA12 is a potential calcium-dependent cell-adhesion protein. PCDHA12 may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Molecular Weight 99 kDa
Gene ID 56137
NCBI Accession NM_018903, NP_061726
UniProt Q9UN75
Research Area Cancer
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 941 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Schmutz, Martin, Terry et al.: "The DNA sequence and comparative analysis of human chromosome 5." in: Nature, Vol. 431, Issue 7006, pp. 268-74, 2004 (PubMed).

Validation Images
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