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Aminomethyltransferase antibody (AMT) (N-Term)

Details for Product anti-AMT Antibody No. ABIN406388, Supplier: Login to see New
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Antigen
Synonyms F16J13.200, F16J13_200, T7P1.13, T7P1_13, wu:fc31f04, wu:fd44b12, wu:fd54h12, zgc:103483, zgc:109741, GCE, GCST, GCVT, NKH, EG434437
Epitope
N-Term
(10), (7), (4), (4), (2), (2), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(30), (5), (5), (3)
Host
Rabbit
(22), (8)
Clonality
Polyclonal
Application
Western Blotting (WB)
(28), (5), (5), (4), (3), (3), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human AMT
Blocking Peptide Blocking peptide for this product available: ABIN973187
Sequence QRAVSVVARL GFRLQAFPPA LCRPLSCAQE VLRRTPLYDF HLAHGGKMVA
Predicted Reactivity Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Zebrafish : 90 %, African clawed frog : 80 %
Characteristics This is a rabbit polyclonal antibody against AMT. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name AMT (AMT Antibody Abstract)
Background The enzyme system for cleavage of glycine (glycine cleavage system, EC 2.1.2.10), which is confined to the mitochondria, is composed of 4 protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). Glycine encephalopathy (GCE) may be due to a defect in any one of these enzymes.The enzyme system for cleavage of glycine (glycine cleavage system, EC 2.1.2.10), which is confined to the mitochondria, is composed of 4 protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase, MIM 238300), H protein (a lipoic acid-containing protein, MIM 238330), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase, MIM 238331). Glycine encephalopathy (GCE, MIM 605899) may be due to a defect in any one of these enzymes.
Molecular Weight 44 kDa
Gene ID 275
NCBI Accession NM_000481, NP_000472
UniProt P48728
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 403 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Aminomethyltransferase antibody (AMT) (N-Term) (ABIN406388) WB Suggested Anti-AMT Antibody Titration: 0.2-1 ug/ml
Positive Control: ...
Background publications Kure, Kato, Dinopoulos et al.: "Comprehensive mutation analysis of GLDC, AMT, and GCSH in nonketotic hyperglycinemia." in: Human mutation, Vol. 27, Issue 4, pp. 343-52, 2006 (PubMed).

Catalog No. ABIN406388
$289.00
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