Tu Translation Elongation Factor, Mitochondrial (Tufm) (Middle Region) antibody

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Antigen
Synonyms TUFM, D250, fi06f04, wu:fi06f04, zgc:110766, COXPD4, EF-TuMT, EFTU, P43, 2300002G02Rik, C76308, C76389
Epitope
Middle Region
(19), (16), (6), (6), (5), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio)
(58), (8), (7), (1), (1), (1), (1)
Host
Rabbit
(50), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(44), (30), (12), (6), (5), (5), (4), (2), (1)
Pubmed 2 references available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human TUFM
Blocking Peptide Blocking peptide for this product available: Tu Translation Elongation Factor, Mitochondrial (Tufm) (Middle Region) peptide (ABIN985750)
Sequence PEKELAMPGE DLKFNLILRQ PMILEKGQRF TLRDGNRTIG TGLVTNTLAM
Predicted Reactivity Dog : 100 %, Rabbit : 90 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against TUFM. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TUFM (Tufm Antibody Abstract)
Background TUFM is a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17.
Molecular Weight 50 kDa
Gene ID 7284
NCBI Accession NM_003321, NP_003312
UniProt P49411
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 455 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Tu Translation Elongation Factor, Mitochondrial (Tufm) (Middle Region) antibody (ABIN406708) WB Suggested Anti-TUFM Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Western Blotting (WB) image for anti-Tu Translation Elongation Factor, Mitochondrial (Tufm) (Middle Region) antibody (ABIN406708) Host: Rabbit
Target Name: TUFM
Sample Tissue: Human Fetal Lung
A...
Product cited in: Clemente, Peralta, Cruz-Bermudez et al.: "hCOA3 stabilizes cytochrome c oxidase 1 (COX1) and promotes cytochrome c oxidase assembly in human mitochondria." in: The Journal of biological chemistry, Vol. 288, Issue 12, pp. 8321-31, 2013 (PubMed).

Background publications Valente, Tiranti, Marsano et al.: "Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu." in: American journal of human genetics, Vol. 80, Issue 1, pp. 44-58, 2006 (PubMed).

Catalog No. ABIN406708
$289.00
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